Bone marrow stem cells transplanted to the testis of sterile mice do not differentiate into spermatogonial stem cells and have no protective effect on.

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Bone marrow stem cells transplanted to the testis of sterile mice do not differentiate into spermatogonial stem cells and have no protective effect on fertility  Dorien Van Saen, M.Sc., Ellen Goossens, Ph.D., Gert De Block, Herman Tournaye, M.D., Ph.D.  Fertility and Sterility  Volume 91, Issue 4, Pages 1549-1552 (April 2009) DOI: 10.1016/j.fertnstert.2008.09.036 Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

Figure 1 (A–C) Identification of GFP+ cells after transplantation using immunohistochemistry. (A) Donor-derived spermatogenesis after SSCT. (B) GFP+ cell in the testicular lumen after bone marrow stem cell transplantation (BMSCT). (C) GFP+ cell in interstitium after BMSCT. (D) Hematoxylin and eosin (H & E) staining: structure of testis, 9 months after BMSCT. (E) Percentage of mice that had a successful pregnancy during a 7-month period. The fertile group was used to determine the number of pregnancies. Fertility and Sterility 2009 91, 1549-1552DOI: (10.1016/j.fertnstert.2008.09.036) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

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