Safety and Efficacy of Teduglutide After 52 Weeks of Treatment in Patients With Short Bowel Intestinal Failure Stephen J.D. O'Keefe, Palle B. Jeppesen,

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Safety and Efficacy of Teduglutide After 52 Weeks of Treatment in Patients With Short Bowel Intestinal Failure Stephen J.D. O'Keefe, Palle B. Jeppesen, Richard Gilroy, Marek Pertkiewicz, Johane P. Allard, Bernard Messing Clinical Gastroenterology and Hepatology Volume 11, Issue 7, Pages 815-823.e3 (July 2013) DOI: 10.1016/j.cgh.2012.12.029 Copyright © 2013 AGA Institute Terms and Conditions

Figure 1 Flow chart for the 52-week efficacy and safety analysis. Patients who received placebo treatment in the initial 6-month RCT are not included in this report. Clinical Gastroenterology and Hepatology 2013 11, 815-823.e3DOI: (10.1016/j.cgh.2012.12.029) Copyright © 2013 AGA Institute Terms and Conditions

Figure 2 Mean reduction in parenteral support over 52 weeks for the 2 dose levels of teduglutide. Patients enrolled in the extension study were continued on teduglutide at the same dose as they were given during the RCT. Clinical Gastroenterology and Hepatology 2013 11, 815-823.e3DOI: (10.1016/j.cgh.2012.12.029) Copyright © 2013 AGA Institute Terms and Conditions