Effect of melatonin on testicular ischemia/reperfusion injury in rats: is this effect related to the proinflammatory cytokines?  Zehra Kurcer, M.D., Elif Oguz, M.Sc., Hatice Ozbilge, M.D., Fusun Baba, M.D., Nurten Aksoy, Ph.D., Necla Celik, M.Sc.  Fertility and Sterility  Volume 89, Issue 5, Pages 1468-1473 (May 2008) DOI: 10.1016/j.fertnstert.2007.04.065 Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Testis tissue TNF-α (A), IL-1β (B), and IL-6 (C) levels of vehicle- or melatonin-treated Sham and IR groups. Fertility and Sterility 2008 89, 1468-1473DOI: (10.1016/j.fertnstert.2007.04.065) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 2 (A) Hypospermatogenesis, disorganization (thin arrow), and sloughing of epithelial cells in seminiferous tubule (thick arrow) in IR group of ipsilateral testis (H-E, ×100). (B) Similar histologic changes (arrow) observed in IR group of contralateral testis (H-E, ×100). (C) Formation of mature spermatids: heads (arrowheads) and tails (thin arrows) and disorganization (thick arrow) observed together in same tubule in IR group of ipsilateral testis after melatonin treatment (H-E, ×100). (D) Normal spermatogenesis observed in Sham group (H-E, ×200). Fertility and Sterility 2008 89, 1468-1473DOI: (10.1016/j.fertnstert.2007.04.065) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions