Histopathologic features (all images at ×10 magnification).

Slides:

Advertisements

Similar presentations

Histogenic analysis confirms prostate cancer metastasis to lung.

Advertisements

Immunologic effects of F16-IL2 therapy.

Anti-CD20 monoclonal antibody treatment in 6 patients with therapy-refractory chronic graft-versus-host disease by Marijke R. Canninga-van Dijk, Hanneke.

by Thomas S. Uldrick, and Richard F. Little

Clinical response to F16-IL2 and LDAC in patients with AML bone marrow involvement. Clinical response to F16-IL2 and LDAC in patients with AML bone marrow.

Intravascular Large B Cell Lymphoma Presenting as Transient Erythema Nodosum-Like Lesions and Fever David J. Tsoulis, MD, Danny Ghazarian, MD, Eugenia.

Figure Neuroimaging and pathology

Nat. Rev. Urol. doi: /nrurol

TIE2hi/VEGFAhi TEMs are present in the TMEM

IHC staining of FFPE esophageal tissues in tissue microarrays (×20).

Case 5 (type 3). Case 5 (type 3). A and B, Postmortem axial (A) and coronal (B) T2-weighted images show atrophied cerebellar cortices with dilation of.

Figure 1 Histopathologic features of a chronic active and a chronic plaque in the MS brain Histopathologic features of a chronic active and a chronic plaque.

Figure 1 Muscle biopsy images demonstrating a pauci-immune necrotizing autoimmune myopathy in illustrative cases 1 and 2 (A–D) Case 1 deltoid muscle. Muscle.

Representative multiplex immunofluorescence image of synovial sarcoma with increased PD-L1/PD-1/CD8 cell densities at the tumor-invasive margin demonstrating.

Figure Brain MRI and biopsy specimens from the pontine lesion

Figure Nuclear Nrf2 expression after fumarate therapy A new left occipital fluid-attenuated inversion recovery hyperintense (A), T1 hypointense (B), and.

Figure 2 Histochemical and immunohistochemical staining and electron microscopic examination of structures in the brain biopsy Hematoxylin & eosin staining.

Figure 4 Neuropathology of MOG and AQP4 antibody–associated demyelinating lesions in the brain The biopsy specimen revealed a small actively demyelinating.

Figure MRI and neuropathologic characteristics of the tumefactive demyelinating lesion in our patient MRI and neuropathologic characteristics of the tumefactive.

Figure 4 Representative images of skin biopsy sample

Figure Radiologic and pathologic findings Fluid-attenuated inversion recovery (FLAIR) sequence with a single large T2-hyperintense signal involving the.

Carlos A. Roldan et al. JIMG 2013;6:

CD169+ macrophages mediate Lm translocation to the splenic T cell zones. CD169+ macrophages mediate Lm translocation to the splenic T cell zones. (A) Confocal.

Figure 3. Brain imaging and neuropathologic studies in patient PT-5 diagnosed with progressive multifocal leukoencephalopathy Brain imaging and neuropathologic.

Figure 2 Pathologic diagnosis of CAA-related vascular inflammation Hematoxylin & eosin staining (A) revealed focal intramural inflammation including lymphocytes,

Continued. Continued. E, Light microscopic image of the left hippocampus obtained by amygdalohippocampectomy reveals extensive neuronal loss and gliosis.

Figure 4 Autopsy immunochemistry results

Corticobasal degeneration (CBD), case 1.

Instigating, noninstigating, and responding human tumor specimens.

Figure 2 Histopathological features in CIDP

Luxol fast blue–stained section from the brain slice imaged in figure 1. Luxol fast blue–stained section from the brain slice imaged in figure 1. The outlined.

Figure MRI brain comparison prior and after treatment and brain biopsy findings MRI brain comparison prior and after treatment and brain biopsy findings.

Figure 2 Brain biopsy of 2 patients with anti-MOG encephalitis initially misdiagnosed with small vessel CNS vasculitis Brain biopsy of 2 patients with.

NRP1-expressing macrophages accumulate in adipose tissue during DIO and regulate weight gain and glucose tolerance. NRP1-expressing macrophages accumulate.

A 53-year-old male patient with temporal lobe epilepsy (case 31).

SIRT1 is downregulated in human gastric cancer (GC).

CD169+ macrophages mediate the transport of bacteria to T cell zones by trans-infecting CD8α+ DCs. CD169+ macrophages mediate the transport of bacteria.

Intratumoral platelet aggregate formation in a murine preclinical glioma model depends on podoplanin expression on tumor cells by Barbara Costa, Tanja.

A: Spindle cells are arranged in sheets and short fascicles admixed with plasma cells (hematoxylin and eosin stain, ×400). A: Spindle cells are arranged.

Hematoxylin-eosin (A) and luxol fast blue (B) staining of the lesion seen in the cerebellum of case 2. Hematoxylin-eosin (A) and luxol fast blue (B) staining.

Apoptosis in CAM vessels after staining with TUNEL

Interacting MDSCs and mast cells (MC) in human colon carcinoma and in the colon of AOM/DSS-induced tumor-bearing mice. Interacting MDSCs and mast cells.

Geographic colocalization of PD-L1+ tumor cells with infiltrating immune cells in MCC. The predominant pattern of tumor cell PD-L1 expression is at the.

IL32 is highly expressed in mycosis fungoides lesional skin.

SDF-1/CXCR4 axis is involved in CD133+ tumor cell metastasis toward a lymphatic metastasis niche. SDF-1/CXCR4 axis is involved in CD133+ tumor cell metastasis.

IL6 mRNA is not detected in metastatic prostate cancer cells.

CD8, galectin-3, galectin-9, and the M1/M2 ratio are associated with a longer survival. CD8, galectin-3, galectin-9, and the M1/M2 ratio are associated.

In vivo thrombosis of tumor vasculature.

Images of a 52-year-old man who developed acute left hemiparesis, ataxia, and agitation (case 1). Images of a 52-year-old man who developed acute left.

Circulating leukocytes are undetectable in blood vessels of solid tumors in RIP1-Tag2 mice even after IL-15/IL-15Rα complex treatment. Circulating leukocytes.

Representative FFPE sections of subcutaneous xenografts derived from HBEC3p53,KRAS and HBEC3p53,KRAS,MYC. Representative FFPE sections of subcutaneous.

Reduced klotho expression in pancreatic cancer.

In vivo demonstration of EMT in GFP-tagged tumors.

Typical histopathologic features of CAPNON

Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8 and Stat3+/+:HPV8 mice. Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8.

Progastrin staining in colon adenomas and adenocarcinomas.

Representative images for different populations of detected cells in prostate cancer patients and five rounds of FISH in a CTC. A, Immunofluorescence image.

A left centrum semiovale lesion in a 30-year-old woman with relapsing-remitting MS; the time lapse between 3T and 7T scans was 6 months. A left centrum.

Renal biopsy specimen from a patient with IgA nephropathy and macroscopic hematuria–associated AKI. Light micrographs show mesangial proliferation, increased.

Metastatic adenocarcinoma.

Coculture with U937 cells enhances DNMT1 expression in gastric cancer cells. Coculture with U937 cells enhances DNMT1 expression in gastric cancer cells.

Recruitment of CD8+, CD4+, and Foxp3+ cells into oral lesions in response to anti–PD-1 treatment. Recruitment of CD8+, CD4+, and Foxp3+ cells into oral.

CD36 expression in tissue adjacent and distal to the tumor.

A, Recurrent neoplasm in patient 6.

A: Lesion showing diffuse aggregates of large histiocytoid cells with abundant cytoplasm that admixed with lymphocytes, plasma cells, and neutrophils (hematoxylin.

PEGPH20 depletes HA and decompresses intratumoral vessels.

IHC staining of FFPE esophageal tissues in tissue microarrays (×20).

Corticobasal degeneration (CBD), case 3.

Reduced pathological damage in lungs and spleens of guinea pigs infected with H37Rv upon AZD0530 treatment. Reduced pathological damage in lungs and spleens.

GSN and DNMT1 expression are inversely correlated in a pattern associated with patient survival. GSN and DNMT1 expression are inversely correlated in a.

Presentation transcript:

Histopathologic features (all images at ×10 magnification). Histopathologic features (all images at ×10 magnification). A, luxol–hematoxylin and eosin (H&E) stain from right frontal lesion, showing a central blood vessel with mild lymphocytic cuffing (arrows), area of severe astrocytic gliosis (bottom left), sheets of macrophages (bottom right, arrowheads), and residual myelin (blue, top left). B, immunohistochemistry for CD68, labeling macrophages (arrows). C, CD45 stain revealing lymphocytes (arrow). D and E, CD4 and CD8 stains, respectively, showing a mixture of T-helper and T-cytotoxic cells. F, luxol–H&E stain from left temporoparietal lesion, showing sheets of macrophages in the bottom left of the image, surrounded by residual myelin (blue) in white matter. Catherine Maurice et al. Cancer Immunol Res 2015;3:1299-1302 ©2015 by American Association for Cancer Research