The influence of bypass temperature on the systemic inflammatory response and organ injury after pediatric open surgery: A randomized trial Christian.

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Presentation transcript:

The influence of bypass temperature on the systemic inflammatory response and organ injury after pediatric open surgery: A randomized trial Christian F. Stocker, MD, Lara S. Shekerdemian, MD, Stephen B. Horton, PhD, Katherine J. Lee, PhD, Rob Eyres, MD, Yves D’Udekem, MD, PhD, Christian P. Brizard, MD The Journal of Thoracic and Cardiovascular Surgery Volume 142, Issue 1, Pages 174-180 (July 2011) DOI: 10.1016/j.jtcvs.2011.01.059 Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Markers of acute inflammation. Absolute changes in markers for acute inflammation, acute phase reaction, and innate immunity from baseline measurements; data are expressed as mean ± standard error. *P < .05 for differences between treatment groups. TLR-2, TLR-4, and mHLA-DR data were only available for 8 patients in each group at each time point. The analysis used all available data. SE, Standard error; CPB, cardiopulmonary bypass; off xcl, crossclamp off; AP, arterial pressure; TNF-α, tumor necrosis factor-α; IL, interleukin; mHLA-DR, monocyte human leucocyte antigen-DR; TLR-2/-4, toll-like receptor 2/4; CRP, C-reactive protein; WCC, total white cell count; ITR, immature-to-total neutrophil ratio. The Journal of Thoracic and Cardiovascular Surgery 2011 142, 174-180DOI: (10.1016/j.jtcvs.2011.01.059) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Hemodynamics, markers of organ injury, and coagulation profile. Absolute changes in hemodynamic indices, markers for organ injury, and coagulation from baseline measurements; data are expressed as mean ± standard error. In the 24°C and 34°C arms, heart rate data were missing for 15 time points in 7 patients and for 12 time points in 7 patients, respectively; mean arterial pressure data were missing for 18 time points in 9 patients and 22 time points in 16 patients, respectively; oxygenation index data were missing for 47 time points in 23 patients and 45 time points in 22 patients, respectively; lactate data were missing for 30 time points in 18 patients and 34 time points in 20 patients, respectively; inotropic score data were missing for 9 time points in 5 patients and 4 time points in 3 patients, respectively; creatinine data were missing for 52 time points in 16 patients and 42 time points in 15 patients, respectively; microalbuminuria data were missing for 28 time points in 12 patients and 24 time points in 8 patients, respectively; S100B data were missing for 6 time points in 2 patients and 5 time points in 3 patients, respectively; prothrombin time data were missing for 21 time points in 11 patients and 19 time points in 8 patients, respectively; activated partial thromboplastin time data were missing for 21 time points in 12 patients and 22 time points in 9 patients, respectively; and platelet count data were missing for 23 time points in 11 patients and 21 time points in 7 patients, respectively. SE, Standard error; CPB, cardiopulmonary bypass; off xcl, crossclamp off; AP, arterial pressure; PT, prothrombin time; aPTT, activated partial thromboplastin time. The Journal of Thoracic and Cardiovascular Surgery 2011 142, 174-180DOI: (10.1016/j.jtcvs.2011.01.059) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions