Volume 4, Issue 3, Pages (April 2018)

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Volume 4, Issue 3, Pages 235-238 (April 2018) Aromatase inhibitor for the treatment of primary mucinous carcinoma of the skin with distant metastasis Hideaki Miyachi, MD, PhD, Hiroyo Hashimoto, MD, Keisuke Suehiro, MD, Yosuke Yamamoto, MD, Satoshi Ota, MD, PhD, Yukio Nakatani, MD, PhD, Hiroyuki Matsue, MD, PhD JAAD Case Reports Volume 4, Issue 3, Pages 235-238 (April 2018) DOI: 10.1016/j.jdcr.2017.10.021 Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Clinical features of the first recurrence in patient with primary mucinous carcinoma of the skin. Multiple red nodules appeared in the left temporal region 2 years after the initial excision. JAAD Case Reports 2018 4, 235-238DOI: (10.1016/j.jdcr.2017.10.021) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Imaging of patient with primary mucinous carcinoma of the skin with [18F]-fluorodeoxy-D-glucose (FDG) positron emission tomography–computed tomography (PET-CT). A, Four months before the treatment with letrozole, FDG PET-CT demonstrated cutaneous (not shown) and subcutaneous (left red circular outline) masses, with FDG uptake in the left cervical lymph node and right lower lung lobe (S6) (middle and right red circular outline). B, Eight months after starting letrozole treatment. FDG uptake had decreased in the cutaneous and subcutaneous masses (left red circular outline) and the lung metastasis (right red circular outline). Moreover, FDG uptake of the cervical lymph node metastasis had disappeared (middle red circular outline). JAAD Case Reports 2018 4, 235-238DOI: (10.1016/j.jdcr.2017.10.021) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 3 Histopathologic features of cutaneous recurrence of primary mucinous carcinoma of the skin. Well-circumscribed mucinous lesion separated into compartments by strands of fibrous tissue. In each compartment, basophilic neoplastic cells with nuclear atypia and mitosis, some forming tubular lumens, are seen floating in the mucinous lesion. Neoplastic cells are positive for cytokeratin 7 and strongly positive for estrogen receptor. JAAD Case Reports 2018 4, 235-238DOI: (10.1016/j.jdcr.2017.10.021) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions