Uwe G. Kersting, Ph. D. , Johann J. Stubendorff, M. D. , Matthias C

Slides:

Advertisements

Similar presentations

Functional ankle instability as a risk factor for osteoarthritis: using T2-mapping to analyze early cartilage degeneration in the ankle joint of young.

Advertisements

In vivo patellofemoral contact mechanics during active extension using a novel dynamic MRI-based methodology B.S. Borotikar, F.T. Sheehan Osteoarthritis.

Validity and responsiveness of a new measure of knee osteophytes for osteoarthritis studies: data from the osteoarthritis initiative M. Hakky, M. Jarraya,

The short-term effects of running on the deformation of knee articular cartilage and its relationship to biomechanical loads at the knee M. Boocock,

T1ρ relaxation time of the meniscus and its relationship with T1ρ of adjacent cartilage in knees with acute ACL injuries at 3T R.I. Bolbos, Ph.D., T.M.

Functional cartilage MRI T2 mapping: evaluating the effect of age and training on knee cartilage response to running T.J. Mosher, Y. Liu, C.M. Torok

Considerations in measuring cartilage thickness using MRI: factors influencing reproducibility and accuracy S. Koo, M.S., G.E. Gold, M.D., T.P. Andriacchi,

T1ρ and T2 relaxation times predict progression of knee osteoarthritis

Long-term periarticular bone adaptation in a feline knee injury model for post-traumatic experimental osteoarthritis S.K. Boyd, Ph.D., R. Müller, Ph.D.,

An MRI derived articular cartilage visualization framework

Acute joint pathology and synovial inflammation is associated with increased intra- articular fracture severity in the mouse knee J.S. Lewis, W.C. Hembree,

Patient-specific chondrolabral contact mechanics in patients with acetabular dysplasia following treatment with peri-acetabular osteotomy C.L. Abraham,

Relationships between tibial rim alignment and joint space width measurement reproducibility in non-fluoroscopic radiographs of osteoarthritic knees

Three-dimensional MRI-based statistical shape model and application to a cohort of knees with acute ACL injury V. Pedoia, D.A. Lansdown, M. Zaid, C.E.

Evolution of semi-quantitative whole joint assessment of knee OA: MOAKS (MRI Osteoarthritis Knee Score) D.J. Hunter, A. Guermazi, G.H. Lo, A.J. Grainger,

J. Duryea, Ph. D. , G. Neumann, M. D. , M. H. Brem, M. D. , W. Koh, M

Women have thinner cartilage and smaller joint surfaces than men after adjustment for body height and weight I.G. Otterness, Ph.D., F. Eckstein, M.D.

Biochemical cartilage alteration and unexpected signal recovery in T2

Determination of in-vivo articular cartilage contact areas of human talocrural joint under weightbearing conditions L. Wan, B.S., R.J. de Asla, M.D.,

Differences between X-ray and MRI-determined knee cartilage thickness in weightbearing and non-weight-bearing conditions M. Marsh, R.B. Souza, B.T.

A.S. Aula, J. Töyräs, V. Tiitu, J.S. Jurvelin

A new non-invasive method to assess synovitis severity in relation to symptoms and cartilage volume loss in knee osteoarthritis patients using MRI J.-P.

Effects of ACL interference screws on articular cartilage volume and thickness measurements with 1.5 T and 3 T MRI M.E. Bowers, B.S., G.A. Tung, M.D.,

Quantification of ankle articular cartilage topography and thickness using a high resolution stereophotography system S.A. Millington, B.M.B.S., M.R.C.S.

A clinically realistic large animal model of intra-articular fracture that progresses to post- traumatic osteoarthritis J.E. Goetz, D. Fredericks, E.

Comparison of load responsiveness of cartilage T1rho and T2 in porcine knee joints: an experimental loading MRI study H. Hamada, T. Nishii, S. Tamura,

Metabolic enrichment of omega-3 polyunsaturated fatty acids does not reduce the onset of idiopathic knee osteoarthritis in mice A. Cai, E. Hutchison,

A. Hosseini, S. K. Van de Velde, M. Kozanek, T. J. Gill, A. J

B. C. Fleming, H. L. Oksendahl, W. A. Mehan, R. Portnoy, P. D

L. McCann, E. Ingham, Z. Jin, J. Fisher Osteoarthritis and Cartilage

Between-group differences in infra-patellar fat pad size and signal in symptomatic and radiographic progression of knee osteoarthritis vs non-progressive.

P. -H. Tsai, M. -C. Chou, H. -S. Lee, C. -H. Lee, H. -W. Chung, Y. -C

Automatic morphometric cartilage quantification in the medial tibial plateau from MRI for osteoarthritis grading E.B. Dam, Ph.D., J. Folkesson, M.Sc.,

Articular cartilage MR imaging and thickness mapping of a loaded knee joint before and after meniscectomy Y. Song, M.S., J.M. Greve, M.S., D.R. Carter,

Intra- and inter-observer reproducibility of volume measurement of knee cartilage segmented from the OAI MR image set using a novel semi-automated segmentation.

T. Nozaki, Y. Kaneko, H. Yu, K. Kaneshiro, R. Schwarzkopf, T. Hara, H

Diagnostic performance of knee ultrasonography for detecting degenerative changes of articular cartilage S. Saarakkala, P. Waris, V. Waris, I. Tarkiainen,

DGEMRIC as a tool for measuring changes in cartilage quality following high tibial osteotomy: a feasibility study M. Rutgers, L.W. Bartels, A.I. Tsuchida,

A. A. Qazi, M. Sc. , J. Folkesson, M. Sc. , P. C. Pettersen, M. D. , M

J. Ranstam Osteoarthritis and Cartilage

Is increased joint loading detrimental to obese patients with knee osteoarthritis? A secondary data analysis from a randomized trial M. Henriksen, D.J.

A relationship between mechanically-induced changes in serum cartilage oligomeric matrix protein (COMP) and changes in cartilage thickness after 5 years

H. Sadeghi, D.E.T. Shepherd, D.M. Espino Osteoarthritis and Cartilage

Early radiographic osteoarthritis is associated with substantial changes in cartilage volume and tibial bone surface area in both males and females1 1.

Quantification of cartilage loss in local regions of knee joints using semi- automated segmentation software: analysis of longitudinal data from the Osteoarthritis.

Dr J. H. Naish, Ph. D. , Dr E. Xanthopoulos, Ph. D. , Dr C. E

G. Neumann, D. Hunter, M. Nevitt, L. B. Chibnik, K. Kwoh, H. Chen, T

F.W. Roemer, M.D. Osteoarthritis and Cartilage

Volumetric bone mineral density of the tibia is not increased in subjects with radiographic knee osteoarthritis M. Abdin-Mohamed, M.B.B.S., M.R.C.P.,

Influence of medial meniscectomy on stress distribution of the femoral cartilage in porcine knees: a 3D reconstructed T2 mapping study T. Shiomi, T.

Functional ankle instability as a risk factor for osteoarthritis: using T2-mapping to analyze early cartilage degeneration in the ankle joint of young.

In vivo imaging of cartilage degeneration using μCT-arthrography

A novel method for assessing signal intensity within infrapatellar fat pad on MR images in patients with knee osteoarthritis M. Lu, Z. Chen, W. Han,

MRI-derived T2 relaxation times and cartilage morphometry of the tibio-femoral joint in subjects with and without osteoarthritis during a 1-year follow-up

X. Li, Ph. D. , C. Benjamin Ma, M. D. , T. M. Link, M. D. , D. -D

Surface roughness and thickness analysis of contrast-enhanced articular cartilage using mesh parameterization T. Maerz, M.D. Newton, H.W.T. Matthew,

D.J. Hunter Osteoarthritis and Cartilage

Quantitative 3D MR evaluation of autologous chondrocyte implantation in the knee: feasibility and initial results C. Glaser, M.D., B.J. Tins, M.D., F.R.C.R.,

M. S. Swanson, J. W. Prescott, T. M. Best, K. Powell, R. D. Jackson, F

Computed tomography topographic mapping of subchondral density (CT-TOMASD) in osteoarthritic and normal knees: methodological development and preliminary.

I. G. Otterness, Ph. D. , M. -P. H. Le Graverand, M. D. , Ph. D. , F

Correlation between the MR T2 value at 4

Knee cartilage defects in a sample of older adults: natural history, clinical significance and factors influencing change over 2.9 years J. Carnes, O.

C. R. Henak, E. D. Carruth, A. E. Anderson, M. D. Harris, B. J

Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen.

CT imaging for evaluation of calcium crystal deposition in the knee: initial experience from the Multicenter Osteoarthritis (MOST) study D. Misra, A.

B. C. Fleming, H. L. Oksendahl, W. A. Mehan, R. Portnoy, P. D

M. E. Bowers, B. S. , N. Trinh, M. S. , G. A. Tung, M. D. , F. A. C. R

Central and peripheral region tibial plateau chondrocytes respond differently to in vitro dynamic compression S.L. Bevill, P.L. Briant, M.E. Levenston,

Measurement of synovial fluid volume using urea

Presentation transcript:

Changes in knee cartilage volume and serum COMP concentration after running exercise Uwe G. Kersting, Ph.D., Johann J. Stubendorff, M.D., Matthias C. Schmidt, M.D., Gert-Peter Brüggemann, Ph.D. Osteoarthritis and Cartilage Volume 13, Issue 10, Pages 925-934 (October 2005) DOI: 10.1016/j.joca.2005.06.005 Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

Fig. 1 Semi-automated segmentation of knee joint cartilage from MRI images. A: Manual editing of the joint surface including the edges of the cartilage layer in the sagittal slice (white line). Arrows indicate the sites where fully automated techniques may require interactive editing. B: Generated image which allows for a fully automated edge detection and subsequent three-dimensional reconstruction of the cartilage volume. Comparable procedures were applied for the tibial and patellar cartilage layers. Osteoarthritis and Cartilage 2005 13, 925-934DOI: (10.1016/j.joca.2005.06.005) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

Fig. 2 Illustration of a segmented and reconstructed knee. View from anterior, medial inferior. x=anterior, y=medial, z=proximal. Osteoarthritis and Cartilage 2005 13, 925-934DOI: (10.1016/j.joca.2005.06.005) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

Fig. 3 Schematic of the procedure designed to allocate the contact elements in the foot coordinate system. A: foot outline with projections of anatomical landmarks, B: 1:1 printout of maximum pressure picture, C: determination of coordinates for contact elements, tibio-talar joint (TTJ) and subtalar joint (STJ) in the foot system, D: generation of a foot mask to calculate force time curves. The in-shoe pressure distribution was measured during running trials. Force–time curves were calculated using Novel-win software (Novel GmbH, Munich, Germany). Osteoarthritis and Cartilage 2005 13, 925-934DOI: (10.1016/j.joca.2005.06.005) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

Fig. 4 Relative cartilage volume post-exercise. Results are given for total volume and separate cartilage bodies (**P<0.01; *P<0.05) for the whole sample. No differences were demonstrated between male and female athletes. Osteoarthritis and Cartilage 2005 13, 925-934DOI: (10.1016/j.joca.2005.06.005) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

Fig. 5 Effective joint loading. These graphs represent the effective joint contact forces and torques in the joint coordinate system of the tibia. Only marginal, statistically non-significant differences between male and female runners were observed. Osteoarthritis and Cartilage 2005 13, 925-934DOI: (10.1016/j.joca.2005.06.005) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

Fig. 6 Graphical presentation of linear correlations for the change in cartilage volume and resting COMP (A) and the change in serum COMP concentration (B). Osteoarthritis and Cartilage 2005 13, 925-934DOI: (10.1016/j.joca.2005.06.005) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

Fig. 7 Joint forces in sagittal plane. A: graphical representation of the joint contact forces. B: Average forces for the whole sample. Osteoarthritis and Cartilage 2005 13, 925-934DOI: (10.1016/j.joca.2005.06.005) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions