Thrombosis in flowing blood

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Thrombosis in flowing blood by Alec A. Schmaier, and Alvin H. Schmaier Blood Volume 114(4):754-756 July 23, 2009 ©2009 by American Society of Hematology

Mechanisms for thrombin generation by collagen in vivo. Mechanisms for thrombin generation by collagen in vivo. In flowing blood where there are shear forces, platelets adhere to exposed collagen. Slowed platelets additionally bind to collagen via glycoprotein VI (GPVI). The GPVI-collagen interaction results in platelet activation. Independently, exposed collagen supports zymogen factor XII (XII) autoactivation to enzymatic factor XIIa (XIIa). XIIa initiates thrombin generation through a series of proteolytic reactions. Thrombin then stimulates platelets by activating its receptors, protease activated receptor 1 (PAR1) and 4 (PAR4). PAR activation and GPVI signaling jointly contribute to a platelet thrombus, which amplifies into a fibrin clot and arterial vessel occlusion. Alec A. Schmaier, and Alvin H. Schmaier Blood 2009;114:754-756 ©2009 by American Society of Hematology