Volume 14, Issue 5, Pages (May 2015)

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Volume 14, Issue 5, Pages 485-496 (May 2015) Association between brain imaging signs, early and late outcomes, and response to intravenous alteplase after acute ischaemic stroke in the third International Stroke Trial (IST-3): secondary analysis of a randomised controlled trial The Lancet Neurology Volume 14, Issue 5, Pages 485-496 (May 2015) DOI: 10.1016/S1474-4422(15)00012-5 Copyright © 2015 The IST-3 collaborative group. Open access article distributed under the terms of CC BY Terms and Conditions

Figure 1 Trial profile The Lancet Neurology 2015 14, 485-496DOI: (10.1016/S1474-4422(15)00012-5) Copyright © 2015 The IST-3 collaborative group. Open access article distributed under the terms of CC BY Terms and Conditions

Figure 2 Forest plot showing the adjusted effect of treatment and baseline imaging signs on Oxford Handicap Scale score 0–2 at 6 months Data are adjusted for age, National Institutes of Health Stroke Scale score, and time to randomisation. The Lancet Neurology 2015 14, 485-496DOI: (10.1016/S1474-4422(15)00012-5) Copyright © 2015 The IST-3 collaborative group. Open access article distributed under the terms of CC BY Terms and Conditions

Figure 3 Forest plot showing the adjusted effect of treatment and baseline imaging signs on symptomatic intracranial haemorrhage within 7 days Data are adjusted for age, National Institutes of Health Stroke Scale score, and time to randomisation. The Lancet Neurology 2015 14, 485-496DOI: (10.1016/S1474-4422(15)00012-5) Copyright © 2015 The IST-3 collaborative group. Open access article distributed under the terms of CC BY Terms and Conditions

Figure 4 Forest plot showing the interaction between response to alteplase and early infarct size in previous trials ASPECTS=Alberta Stroke Programme Early CT Signs. ECASS II=European Co-operative Acute Stroke Study-II. IST-3=third International Stroke Trial. NINDS=National Institute of Neurological Disorders and Stroke. PROACT 2=Prolyse in Acute Cerebral Thromboembolism 2. The Lancet Neurology 2015 14, 485-496DOI: (10.1016/S1474-4422(15)00012-5) Copyright © 2015 The IST-3 collaborative group. Open access article distributed under the terms of CC BY Terms and Conditions