Anti–VLA-4 antibody reduces intimal hyperplasia in the endarterectomized carotid artery in nonhuman primates Alan B. Lumsden, MB, ChB, Changyi Chen,

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Presentation transcript:

Anti–VLA-4 antibody reduces intimal hyperplasia in the endarterectomized carotid artery in nonhuman primates Alan B. Lumsden, MB, ChB, Changyi Chen, MD, PhD, John D. Hughes, MD, Andrew B. Kelly, DVM, Stephen R. Hanson, PhD, Laurence A. Harker, MD Journal of Vascular Surgery Volume 26, Issue 1, Pages 87-93 (July 1997) DOI: 10.1016/S0741-5214(97)70151-4 Copyright © 1997 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Histologic cross-sections at sites of carotid artery endarterectomy. Greater intimal hyperplasia developed in the control arteries (A) than in the arteries treated with anti–VLA-4 monoclonal antibody (B). L, Lumen; I, intima; M, media; A, adventitia. Blue represents collagen staining; black represents elastin staining; pink represents all other components. (Verhoeff-Masson's stain; original magnification ×100.) Journal of Vascular Surgery 1997 26, 87-93DOI: (10.1016/S0741-5214(97)70151-4) Copyright © 1997 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Histologic cross-sections at sites of carotid artery endarterectomy. Greater intimal hyperplasia developed in the control arteries (A) than in the arteries treated with anti–VLA-4 monoclonal antibody (B). L, Lumen; I, intima; M, media; A, adventitia. Blue represents collagen staining; black represents elastin staining; pink represents all other components. (Verhoeff-Masson's stain; original magnification ×100.) Journal of Vascular Surgery 1997 26, 87-93DOI: (10.1016/S0741-5214(97)70151-4) Copyright © 1997 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions