Proposed reaction sequence initiating HMBPP reduction as it was derived from crystallographic data. Proposed reaction sequence initiating HMBPP reduction.

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Proposed reaction sequence initiating HMBPP reduction as it was derived from crystallographic data. Proposed reaction sequence initiating HMBPP reduction as it was derived from crystallographic data. Schematic representation of bound substrate and the 17 member cyclic hydrogen-bonding system including substrate, T167, E126 and W1 depicts the anticipated role of the individual amino acids as proton relay and proton source. Tobias Gräwert et al. PNAS 2010;107:3:1077-1081 ©2010 by National Academy of Sciences