Now or Later: Evaluating the Importance of Chemotherapy Timing in Resectable Stage III (N2) Lung Cancer in the National Cancer Database Daniel J. Boffa,

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Presentation transcript:

Now or Later: Evaluating the Importance of Chemotherapy Timing in Resectable Stage III (N2) Lung Cancer in the National Cancer Database Daniel J. Boffa, MD, Jacquelyn G. Hancock, BS, Xiaopan Yao, PhD, Sarah Goldberg, MD, Joshua E. Rosen, BS, Anthony W. Kim, MD, Amy Moreno, MD, Frank C. Detterbeck, MD The Annals of Thoracic Surgery Volume 99, Issue 1, Pages 200-208 (January 2015) DOI: 10.1016/j.athoracsur.2014.08.040 Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Schema of patient distribution according to treatment and pathologic N2 status. (Chemo = chemotherapy; Postop = postoperative; Preop =preoperative; XRT = radiation.) The Annals of Thoracic Surgery 2015 99, 200-208DOI: (10.1016/j.athoracsur.2014.08.040) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Forrest plot of Cox proportional hazards model in clinical N2 including comparison of postoperative chemotherapy alone to preoperative chemotherapy alone. ∗Variables with fewer than 10 patients were included in the Cox but not represented in the graph because of wide confidence intervals. (BAC = bronchioloalveolar carcinoma; Chemo = chemotherapy; CI = confidence interval; HR = hazard ratio; Postop = postoperative; Preop = preoperative.) The Annals of Thoracic Surgery 2015 99, 200-208DOI: (10.1016/j.athoracsur.2014.08.040) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Forrest plot of Cox proportional hazards model in clinical N2 including comparison of postoperative chemotherapy + radiation with preoperative chemotherapy + radiation. ∗Variables with fewer than 10 patients were included in the Cox but not represented in the graph because of wide confidence intervals. (BAC = bronchioloalveolar carcinoma; Chemo = chemotherapy; CI = confidence interval; HR = hazard ratio; Postop = postoperative; Preop = preoperative.) The Annals of Thoracic Surgery 2015 99, 200-208DOI: (10.1016/j.athoracsur.2014.08.040) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Forrest plot of Cox proportional hazards model in cN2→pN2 patients including comparison of postoperative chemotherapy with or without radiation to surgery alone. ∗Other laterality refers to central tumors. ∗∗Variables with fewer than 10 patients were included in the Cox but not represented in the graph because of wide confidence intervals. (BAC = bronchioloalveolar carcinoma; Chemo = chemotherapy; CI = confidence interval; HR = hazard ratio; Postop = postoperative.) The Annals of Thoracic Surgery 2015 99, 200-208DOI: (10.1016/j.athoracsur.2014.08.040) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions