Experimental Induction of Alopecia Areata-Like Hair Loss in C3H/HeJ Mice Using Full- Thickness Skin Grafts Kevin J. McElwee, Dawnalyn Boggess, John P.

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Experimental Induction of Alopecia Areata-Like Hair Loss in C3H/HeJ Mice Using Full- Thickness Skin Grafts Kevin J. McElwee, Dawnalyn Boggess, John P. Sundberg Journal of Investigative Dermatology Volume 111, Issue 5, Pages 797-803 (November 1998) DOI: 10.1046/j.1523-1747.1998.00380.x Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 AA-affected C3H/HeJ skin when transplanted to a C3H/SmnC Prkdcscid/J mouse. (A) Day 0 immediately before surgery; (B) day 0 immediately after surgery; (C) 80 d post-surgery with white hair growth from the graft. Journal of Investigative Dermatology 1998 111, 797-803DOI: (10.1046/j.1523-1747.1998.00380.x) Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Histology of AA-affected C3H/HeJ skin grafts and C3H/SmnC Prkdcscid/J graft recipients 80 d post-surgery. Transverse section with induced anagen host hair follicles (left) and graft with isolated follicles and scarring (right, A, scale bar: 100 μm). Infiltrate of neutrophils and eosinophils plus isolated mononuclear cells evident in boxed area (B, scale bar: 10 μm). Journal of Investigative Dermatology 1998 111, 797-803DOI: (10.1046/j.1523-1747.1998.00380.x) Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 C3H/SmnC Prkdcscid/J skin transplanted to an AA-affected C3H/HeJ mouse. (A) Day 0 immediately before surgery with extensive diffuse dorsal hair loss plus isolated patchy alopecia; (B) day 0 immediately after surgery with normal, haired C3H/SmnC Prkdcscid/J skin graft; (C) 80 d post-surgery with diffuse, aberrant hair fiber from the graft and diffuse, aberrant host hair proximal and distal to the graft site. Journal of Investigative Dermatology 1998 111, 797-803DOI: (10.1046/j.1523-1747.1998.00380.x) Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 4 Histology of C3H/SmnC Prkdcscid/J skin transplanted onto an AA-affected C3H/HeJ mouse. Transverse section with graft skin plus anagen hair follicles (left) and host skin containing anagen hair follicles (right, scale bar: 100 μm). C3H/SmnC Prkdcscid/J skin graft derived anagen hair follicles with a similar mononuclear cell infiltrate (B, scale bar: 10 μm). Host anagen hair follicles with nonscarring focal peri and intrafolliclular infiltrate of mononuclear cells (C, scale bar: 10 μm). Journal of Investigative Dermatology 1998 111, 797-803DOI: (10.1046/j.1523-1747.1998.00380.x) Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 5 AA-affected C3H/HeJ skin grafted to a normal, haired C3H/HeJ mouse. (A) On day 0 immediately before surgery; (B) on day 0 immediately after surgery; (C) 90 d post-surgery with minimal apparent hair growth from the skin graft, localized hair loss around the graft, and onset of AA in graft recipient distal to the graft site; (D) symmetrical AA in the graft recipient on the ventral surface. Journal of Investigative Dermatology 1998 111, 797-803DOI: (10.1046/j.1523-1747.1998.00380.x) Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 6 Histology of AA-affected C3H/HeJ skin grafted to a normal, haired C3H/HeJ mouse 90 d post-surgery. Transverse section with graft including isolated hair follicles and scar tissue (left) and recipient skin containing hair follicles induced by surgery into anagen (right, A, scale bar: 100 μm). Inflammatory cell infiltrate around graft anagen hair follicles (B, scale bar: 10 μm). Recipient anagen hair follicles associated with a peri and intra bulbar mononuclear cell infiltrate (C, scale bar: 10 μm). Journal of Investigative Dermatology 1998 111, 797-803DOI: (10.1046/j.1523-1747.1998.00380.x) Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions