The GR dimer in stromal cells mediates the induction of genes of anti-inflammatory macrophages after DEX treatment in serum transfer-induced arthritis.

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Presentation transcript:

The GR dimer in stromal cells mediates the induction of genes of anti-inflammatory macrophages after DEX treatment in serum transfer-induced arthritis (STIA). The GR dimer in stromal cells mediates the induction of genes of anti-inflammatory macrophages after DEX treatment in serum transfer-induced arthritis (STIA). (A) Quantitative RT-PCR of isolated ankle mRNA extracts showing the regulation of CD163, CD36, AnxA1, Axl and MerTK after 72 hours of DEX treatment in wt→wt and wt→GRdim mice. Group size n=5–6 mice per group. (B) Quantitative RT-PCR of isolated ankle mRNA extracts showing the regulation of CD163, CD36, AnxA1, Axl and MerTK after 10 days of DEX treatment in wt→wt and wt→GRdim mice. Group size n=4–6 mice per group. *P<0.05; **P<0.01; ***P<0.001 by two-way analysis of variance (ANOVA) followed Tukey’s multiple comparison correction. DEX, dexamethasone; GR, glucocorticoid receptor; PBS, phosphate buffered saline. Mascha Koenen et al. Ann Rheum Dis 2018;77:1610-1618 ©2018 by BMJ Publishing Group Ltd and European League Against Rheumatism