Kirby Siemering, Shehnaaz S. M. Manji, Wendy M

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Detection of Mutations in Genes Associated with Hearing Loss Using a Microarray- Based Approach Kirby Siemering, Shehnaaz S.M. Manji, Wendy M. Hutchison, Desiree Du Sart, Dean Phelan, Hans-Henrik M. Dahl The Journal of Molecular Diagnostics Volume 8, Issue 4, Pages 483-489 (September 2006) DOI: 10.2353/jmoldx.2006.050147 Copyright © 2006 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

Figure 1 A: Layout of the Hearing Loss Biochip (version HL7) showing the six identical blocks of 16 × 8 oligonucleotide spots. B: Organization of oligonucleotides in each block. Oligonucleotides to wild-type sequences are indicated by a -N and to mutant sequences by a -M. The Journal of Molecular Diagnostics 2006 8, 483-489DOI: (10.2353/jmoldx.2006.050147) Copyright © 2006 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

Figure 2 Examples of hybridization signals. A–F: Shown are some of the connexin 26 mutations in panels. The GIs calculated from the hybridization signals of mutant spots are also shown. The Journal of Molecular Diagnostics 2006 8, 483-489DOI: (10.2353/jmoldx.2006.050147) Copyright © 2006 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions