Endocrine and cardiometabolic cord blood characteristics of offspring born to mothers with and without polycystic ovary syndrome Nadine M.P. Daan, M.D.,

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Presentation transcript:

Endocrine and cardiometabolic cord blood characteristics of offspring born to mothers with and without polycystic ovary syndrome Nadine M.P. Daan, M.D., Ph.D., Maria P.H. Koster, M.D., Ph.D., Regine P. Steegers-Theunissen, M.D., Ph.D., Marinus J.C. Eijkemans, Ph.D., B.C.J.M. Fauser, M.D., Ph.D. Fertility and Sterility Volume 107, Issue 1, Pages 261-268.e3 (January 2017) DOI: 10.1016/j.fertnstert.2016.09.042 Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 Box plots reflecting androstenedione concentrations within each study group. The circles represent outliers of >1.5 times the interquartile range, and asterisks represent outliers of >3 times the interquartile range. One asterisk in the female controls is not displayed (29.05 nmol/L). Fertility and Sterility 2017 107, 261-268.e3DOI: (10.1016/j.fertnstert.2016.09.042) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 2 Pearson's correlation coefficients between log-transformed cord blood parameters within male offspring. *P<.05, statistically significant difference. AD = androstenedione; Adipo = adiponectin; CHOL = total cholesterol; CRP = c-reactive protein; DHEAS = dehydroepiandrosterone sulfate; E2 = estradiol; FAI = free androgen index (T/SHBG × 100); HDL = high-density lipoprotein cholesterol; INS = insulin; LDL = low-density lipoprotein cholesterol; PCOS = polycystic ovary syndrome; SHBG = sex hormone-binding globulin; T = testosterone; TRIG = triglycerides. Fertility and Sterility 2017 107, 261-268.e3DOI: (10.1016/j.fertnstert.2016.09.042) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 3 Pearson's correlation coefficients between log-transformed cord blood parameters within female offspring. *P<.05, statistically significant difference. AD = androstenedione; Adipo = adiponectin; CHOL = total cholesterol; CRP = c-reactive protein; DHEAS = dehydroepiandrosterone sulfate; E2 = estradiol; FAI = free androgen index (T/SHBG × 100); HDL = high-density lipoprotein cholesterol; INS = insulin; LDL = low-density lipoprotein cholesterol; PCOS = polycystic ovary syndrome; SHBG = sex hormone-binding globulin; T = testosterone; TRIG = triglycerides. Fertility and Sterility 2017 107, 261-268.e3DOI: (10.1016/j.fertnstert.2016.09.042) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions