Randomized Phase II Trial of Irinotecan with Paclitaxel or Gemcitabine for Non-small Cell Lung Cancer: Association of UGT1A16 and UGT1A127 with Severe.

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Randomized Phase II Trial of Irinotecan with Paclitaxel or Gemcitabine for Non-small Cell Lung Cancer: Association of UGT1A1*6 and UGT1A1*27 with Severe Neutropenia Yoichi Nakamura, MD, PhD, Hiroshi Soda, MD, PhD, Mikio Oka, MD, PhD, Akitoshi Kinoshita, MD, PhD, Minoru Fukuda, MD, PhD, Masaaki Fukuda, MD, PhD, Hiroshi Takatani, MD, PhD, Seiji Nagashima, MD, Yoshifumi Soejima, MD, PhD, Takashi Kasai, MD, PhD, Katsumi Nakatomi, MD, PhD, Noriyuki Masuda, MD, PhD, Kazuhiro Tsukamoto, MD, PhD, Shigeru Kohno, MD, PhD Journal of Thoracic Oncology Volume 6, Issue 1, Pages 121-127 (January 2011) DOI: 10.1097/JTO.0b013e318200e4e8 Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Kaplan-Meier curves for (A) progression-free survival and (B) overall survival. Journal of Thoracic Oncology 2011 6, 121-127DOI: (10.1097/JTO.0b013e318200e4e8) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Linkage disequilibrium analysis for UGT1A1, UGT1A7, and UGT1A9 single-nucleotide polymorphisms. D′ (upper, red) and r2 (lower, blue) values are shown for each square. Journal of Thoracic Oncology 2011 6, 121-127DOI: (10.1097/JTO.0b013e318200e4e8) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions