Empirical mutation-selection phase diagram of tumor evolution.

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Empirical mutation-selection phase diagram of tumor evolution. Empirical mutation-selection phase diagram of tumor evolution. (A) Mutation-selection empirical diagram for all analyzed cancers (gray) and selected cancer types (color-coded) that show distinct evolutionary regimes depending on the ML. (B) A schematic conceptual depiction of the emerging fitness landscape of tumors as a function of the ML (Top) and selection (Bottom). Dashed curves are theoretical, and solid curves are observed. Down-triangles (green) indicate purifying selection and up-triangles (orange) positive selection. The gray ovals show the critical area. Erez Persi et al. PNAS 2018;115:47:E11101-E11110 ©2018 by National Academy of Sciences