Expression of the chemokine receptors CXCR4, CXCR5, and CCR7 in primary central nervous system lymphoma by Kristoph Jahnke, Sarah E. Coupland, Il-Kang.

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Presentation transcript:

Expression of the chemokine receptors CXCR4, CXCR5, and CCR7 in primary central nervous system lymphoma by Kristoph Jahnke, Sarah E. Coupland, Il-Kang Na, Christoph Loddenkemper, Ulrich Keilholz, Agnieszka Korfel, Harald Stein, Eckhard Thiel, and Carmen Scheibenbogen Blood Volume 106(1):384-385 July 1, 2005 ©2005 by American Society of Hematology

Immunohistochemistry and immunofluorescence in PCNSL and peripheral diffuse large B-cell lymphoma stained with anti-CXCR4 antibody. Immunohistochemistry and immunofluorescence in PCNSL and peripheral diffuse large B-cell lymphoma stained with anti-CXCR4 antibody. Immunohistochemistry and immunofluorescence demonstrate the cytoplasmic expression of CXCR4 in PCNSL (A-C) and combined cytoplasmic-membranous staining of CXCR4 in a peripheral diffuse large B-cell lymphoma (D-F). (A,D) CXCR4 staining using conventional immunohistochemistry; the arrow indicates membranous staining (APAAP; original magnification, × 600 using an Olympus AX70 microscope [Olympus, Melville, NY]). (B,E) CXCR4 staining by immunofluorescence (Cy2 labeled); (C,F) combined CXCR4/DAPI immunofluorescence staining (original magnification, ×100 under a 1.30 UPlan FL oil objective lens used with an Olympus BX60 microscope). A ColorView II camera and AnalySIS software (Soft Imaging Systems, Muenster, Germany) were used for image acquisition and processing. Kristoph Jahnke et al. Blood 2005;106:384-385 ©2005 by American Society of Hematology