Paradoxical Rebound Platelet Activation After Painkillers Cessation: Missing Risk for Vascular Events? Victor L. Serebruany, MD, Alex I. Malinin, MD,

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Paradoxical Rebound Platelet Activation After Painkillers Cessation: Missing Risk for Vascular Events? Victor L. Serebruany, MD, Alex I. Malinin, MD, Deepak L. Bhatt, MD The American Journal of Medicine Volume 119, Issue 8, Pages 707.e11-707.e16 (August 2006) DOI: 10.1016/j.amjmed.2005.11.007 Copyright © 2006 Elsevier Inc. Terms and Conditions

Figure 1 Individual plots of 5 μM adenosine diphosphate (ADP)-induced platelet aggregation on top (A) and after withdrawal (B) of nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase-2 (COX-2) inhibitors. Mean, median, and range (bars). The American Journal of Medicine 2006 119, 707.e11-707.e16DOI: (10.1016/j.amjmed.2005.11.007) Copyright © 2006 Elsevier Inc. Terms and Conditions