MMP9 potentiates pulmonary metastasis formation

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MMP9 potentiates pulmonary metastasis formation Léon C.L van Kempen, Lisa M Coussens Cancer Cell Volume 2, Issue 4, Pages 251-252 (October 2002) DOI: 10.1016/S1535-6108(02)00157-5

Figure 1 A model for the role of tumor-associated macrophages and MMP9 in priming premetastatic tissue. Macrophages (Mφ) are recruited to sites of malignant growth. Upon activation by primary tumor (PT) cells, activated macrophages (Mφ∗) expressing MMP9 then reenter the circulation and induce MMP9 expression in (alveolar) endothelial cells (Alv. EC) in a VEGFR-1-dependent manner, thereby prepping premetastatic tissue for malignant cell colonization. Distal organs harboring low-level VEGFR-1 expression are not suitable environments for metastatic growth and fail to induce MMP9 expression in response to the presence of activated macrophages. Cancer Cell 2002 2, 251-252DOI: (10.1016/S1535-6108(02)00157-5)