Calcified Left Ventricular Mass: Unusual Clinical, Echocardiographic, and Computed Tomographic Findings of Primary Cardiac Osteosarcoma Sunil K. Nowrangi, MD, Naser M. Ammash, MD, William D. Edwards, MD, Jerome F. Breen, MD, John H. Edmonson, MD Mayo Clinic Proceedings Volume 75, Issue 7, Pages 743-747 (July 2000) DOI: 10.4065/75.7.743 Copyright © 2000 Mayo Foundation for Medical Education and Research Terms and Conditions
Figure 1 Transthoracic (left) and transesophageal (right) echocardiograms, demonstrating a large calcified left ventricular mass extending from the base of the septum to the posteromedial section of the ventricle. Left, Parasternal long-axis view. Ao = aorta; LA = left atrium; LV = left ventricle; RA = right atrium; RV = right ventricle. Mayo Clinic Proceedings 2000 75, 743-747DOI: (10.4065/75.7.743) Copyright © 2000 Mayo Foundation for Medical Education and Research Terms and Conditions
Figure 2 Noncontrast (left) and contrast-enhanced (right) computed tomograms of heart, showing partially calcified mass (arrows). The small amount of associated noncalcified soft tissue was originally thought to be part of the papillary muscle process. Mayo Clinic Proceedings 2000 75, 743-747DOI: (10.4065/75.7.743) Copyright © 2000 Mayo Foundation for Medical Education and Research Terms and Conditions
Figure 3 Follow-up contrast-enhanced computed tomogram of chest, showing that the partially calcified mass (left) (arrows) has increased in size and that a new nodule (right) (arrowheads) has developed. Mayo Clinic Proceedings 2000 75, 743-747DOI: (10.4065/75.7.743) Copyright © 2000 Mayo Foundation for Medical Education and Research Terms and Conditions
Figure 4 Gross photograph of ventricular slices (short-axis format). Osteosarcoma (white) is massive and involves the inferoseptal aspects of both ventricles, at midventricular and apical levels, and the posteromedial mitral papillary muscle. Mayo Clinic Proceedings 2000 75, 743-747DOI: (10.4065/75.7.743) Copyright © 2000 Mayo Foundation for Medical Education and Research Terms and Conditions
Figure 5 Photomicrograph of primary cardiac osteosarcoma. Malignant spindle cells are associated with focal bone formation (hematoxylin-eosin; original magnification ×300). Mayo Clinic Proceedings 2000 75, 743-747DOI: (10.4065/75.7.743) Copyright © 2000 Mayo Foundation for Medical Education and Research Terms and Conditions