Multiple prevalent fractures in relation to macroscopic bone architecture in patients with cystic fibrosis Mirjam Stahl, Christian Holfelder, Carolin.

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Multiple prevalent fractures in relation to macroscopic bone architecture in patients with cystic fibrosis Mirjam Stahl, Christian Holfelder, Carolin Kneppo, Meinhard Kieser, Christian Kasperk, Eckhard Schoenau, Olaf Sommerburg, Burkhard Tönshoff Journal of Cystic Fibrosis Volume 17, Issue 1, Pages 114-120 (January 2018) DOI: 10.1016/j.jcf.2016.06.004 Copyright © 2016 European Cystic Fibrosis Society Terms and Conditions

Fig. 1 Age distribution in CF patients with and without fractures. Each bar represents a patient, its length reaching up to the age of the patient at time of study. The bar's color symbolizes the number of fractures already acquired. Note the young age of six patients with at least one fracture already in the first five years of life. Journal of Cystic Fibrosis 2018 17, 114-120DOI: (10.1016/j.jcf.2016.06.004) Copyright © 2016 European Cystic Fibrosis Society Terms and Conditions

Fig. 2 Probability of CF patients to remain free of any fracture (Kaplan–Meier method). This probability was reduced to 39.8% in the patient group (n=43; black line) at the age of 25years compared to a probability of 84.6% after 25years (P<0.001) of the general German population aged 0–30years as a control (n=26,370,006 persons; dotted line). Grey horizontal lines represent the 100%, 84.6%, 50%, and 39.8% probability of remaining fracture-free. Crosses indicate censored patients. Journal of Cystic Fibrosis 2018 17, 114-120DOI: (10.1016/j.jcf.2016.06.004) Copyright © 2016 European Cystic Fibrosis Society Terms and Conditions

Fig. 3 Comparison of patients groups according to fracture status for DXA-derived bone parameters. Patients with no or one fracture (white bar, n=35, number restricted to n=32 for all parameters but BMD lumbar spine) show significantly higher z-score values compared to patients with more than one fracture (grey bar, n=8, number restricted to n=7 for all DXA parameters). BMD, bone mineral density; BMC, bone mineral content (head included for adults, head excluded for children). Journal of Cystic Fibrosis 2018 17, 114-120DOI: (10.1016/j.jcf.2016.06.004) Copyright © 2016 European Cystic Fibrosis Society Terms and Conditions