Clinical Microbiology and Infection Treatment challenges in the management of complicated skin and soft-tissue infections  B.I. Eisenstein  Clinical Microbiology and Infection  Volume 14, Pages 17-25 (March 2008) DOI: 10.1111/j.1469-0691.2008.01922.x Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 1 Infected leg ulcer. The patient presented with an infected leg ulcer, the cause of which, methicillin-resistant Staphylococcus aureus, was identified on day 3. Daptomycin therapy was commenced on day 3, and less slough tissue was observed on day 5. Although the treatment was interrupted by the patient between days 7 and 10, recommencement of treatment on day 10 led to noticeable wound healing by day 12. Antibiotic therapy was stopped on day 14, and complete healing of the wound had occurred by day 21. Clinical Microbiology and Infection 2008 14, 17-25DOI: (10.1111/j.1469-0691.2008.01922.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 2 Infected diabetic foot. The patient presented with an infected ulcer on the tip of the fourth toe of the left foot. The patient was hospitalised following assessment by a diabetologist, and initial wound debridement and cultures revealed methicillin-susceptible Staphylococcus aureus and group B β-haemolytic streptococci. Initial antibiotic treatment of the ulcer had no effect on the infection, and further treatment with vancomycin also resulted in insufficient regression of the infection (a). Treatment with daptomycin was commenced and resulted in reduction in the swelling and absence of putrid secretions after 2 days (b). Amputation of the fourth toe was performed on day 10 after admission (day 3 of therapy with daptomycin), and uncomplicated primary wound healing occurred after amputation; daptomycin was discontinued after 7 days (c). Clinical Microbiology and Infection 2008 14, 17-25DOI: (10.1111/j.1469-0691.2008.01922.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions