Volume 4, Issue 4, Pages (May 2018)

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Volume 4, Issue 4, Pages 379-381 (May 2018) Metastatic melanoma with diffuse melanosis histologically after stable response to talimogene laherparepvec therapy Jason M. Rizzo, MD, PhD, Leslie A. Fecher, MD, May P. Chan, MD, Alison B. Durham, MD JAAD Case Reports Volume 4, Issue 4, Pages 379-381 (May 2018) DOI: 10.1016/j.jdcr.2018.01.023 Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Pretreatment and posttreatment clinical appearance. A, Before treatment, numerous blue-black papules coalescing into plaques located diffusely on the scalp. B, After treatment, subjective mild thinning of the plaque and increased hair density noted with no appreciable change in color or surface area involvement. JAAD Case Reports 2018 4, 379-381DOI: (10.1016/j.jdcr.2018.01.023) Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Pretreatment and posttreatment histopathologic appearance. A, Before treatment, a representative biopsy result (injected lesion) shows numerous compact nests of pleomorphic melanoma cells in the upper dermis. A few scattered melanophages filled with brown melanin pigment are also present. B, After treatment, a clinically darkly pigmented lesion is composed of large clusters of melanophages only. No viable melanoma cells are present. (Hematoxylin-eosin stain; original magnification: ×100). JAAD Case Reports 2018 4, 379-381DOI: (10.1016/j.jdcr.2018.01.023) Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions