The Genomics of Cancer and Molecular Testing:

Introduction

Precision Medicine: A Paradigm Shift

Inverted Pyramid: Biomarker-driven Trials

Selected Early-Phase Clinical Trials of Targeted Therapies Using Molecular Matching: Response Rates

The Genetic Code

Oncogenes

Tumor Suppressors

Types of Mutations

Copy Number Alterations

Copy Number Alterations (cont)

Chromosomal Fusions/Translocations/ Rearrangements

Somatic vs Germline Mutations

Genomic Alterations: Challenges in Applying the Data

Determining Whether a Genomic Alteration is Actionable

Definitions

Responses With Targeted Therapy

Unique Molecular Signatures

Standard Markers According to Tumor Type

Multiple Gene Alterations: Lessons From Super-responders (Patient 1) - Results from NGS

Multiple Gene Alterations: Lessons From Super-Responders (Patient 1)

Lessons From Super-Responders: Triple Combo Therapy-Case Study (Patient 2)

Response to Triple Combination Therapy

Clinical Experience: Lessons Learned

Overcoming Resistance: Identifying Precise Alterations

Response to Combination of Erlotinib and Cetuximab in a Patient With NSCLC

Future Approaches

Key Features of Next Generation Trials

Abbreviations

Abbreviations (cont)

Abbreviations (cont)

Abbreviations (cont)

References

References (cont)

References (cont)

References (cont)