Pathological roles of purinergic signaling in the liver Byron P. Vaughn, Simon C. Robson, Geoffrey Burnstock  Journal of Hepatology  Volume 57, Issue 4, Pages 916-920 (October 2012) DOI: 10.1016/j.jhep.2012.06.008 Copyright © 2012 European Association for the Study of the Liver Terms and Conditions

Fig. 1 An overview of the complex interplay between extracellular ATP and adenosine. As illustrated, purinergic signaling influences both the process of inflammation as well as cellular regeneration. Extracellular ATP from biologic stress can incite inflammation. As ATP is metabolized by ectonucleotidases on endothelial surfaces to adenosine, the inflammatory response is regulated through induction of immune suppressive T regulatory cells. This has important implications for potential therapies in malignancy and liver transplantation. Journal of Hepatology 2012 57, 916-920DOI: (10.1016/j.jhep.2012.06.008) Copyright © 2012 European Association for the Study of the Liver Terms and Conditions