Efficacy of predictive models for polycystic ovary syndrome using serum levels of two antimüllerian hormone isoforms (proAMH and AMHN,C) Michael W. Pankhurst,

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Presentation transcript:

Efficacy of predictive models for polycystic ovary syndrome using serum levels of two antimüllerian hormone isoforms (proAMH and AMHN,C) Michael W. Pankhurst, Ph.D., Soulmaz Shorakae, M.D., Raymond J. Rodgers, Ph.D., Helena J. Teede, Ph.D., Lisa J. Moran, Ph.D. Fertility and Sterility Volume 108, Issue 5, Pages 851-857.e2 (November 2017) DOI: 10.1016/j.fertnstert.2017.08.012 Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Total antimüllerian hormone (AMH) (A), AMH proprotein (proAMH) (B), cleaved AMH complex (AMHN,C) (C), and AMH prohormone index (API) (D) concentrations in women with and without polycystic ovary syndrome (PCOS). Blue diamonds, control women (n = 23*); red circles, women with PCOS (n = 45). Groups that share the same letter annotation(s) did not exhibit statistically significant differences in the group means. *Three control participants with total AMH and proAMH below the limit of detection were not included in the analysis in (D) as their API cannot be calculated. Data are presented as medians with interquartile ranges. Fertility and Sterility 2017 108, 851-857.e2DOI: (10.1016/j.fertnstert.2017.08.012) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Figure 2 The relationships between AMH prohormone index (API) and total antimüllerian hormone (AMH) (A), T (testosterone) (B), or cycle regularity (C) in women with and without polycystic ovary syndrome (PCOS). Blue diamonds, control women; red circles, women with PCOS. The dashed line in (A) and (B) indicates the median of the control group. Data in (A) were analyzed by Pearson's correlation and data in (C) were analyzed by general linear models with Tukey's B post-hoc test; groups that share the same letter annotation(s) did not exhibit statistically significant differences in the group means. Error bars, SEM; group sizes are indicated above the x-axis. Fertility and Sterility 2017 108, 851-857.e2DOI: (10.1016/j.fertnstert.2017.08.012) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 Receiver operating characteristic curves for the ability of total antimüllerian hormone (AMH) (A), AMH proprotein (proAMH) (B), cleaved AMH complex (AMHN,C) (C), and AMH prohormone index (API) (D) to predict a diagnosis of polycystic ovary syndrome (PCOS). Fertility and Sterility 2017 108, 851-857.e2DOI: (10.1016/j.fertnstert.2017.08.012) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 2 Multivariate receiver operating characteristic curves for the ability of total antimüllerian hormone (AMH) (A), AMH proprotein (proAMH) (B), cleaved AMH complex (AMHN,C) (C), and AMH prohormone index (API) (D) to predict a diagnosis of polycystic ovary syndrome (PCOS). Multivariate models were generated with PCOS status as the dependent and the AMH parameter, age, free androgen index (FAI), and waist circumference (WC) as the independent variables. Fertility and Sterility 2017 108, 851-857.e2DOI: (10.1016/j.fertnstert.2017.08.012) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions