Triple play of H pylori in ITP

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Triple play of H pylori in ITP by Yeon S. Ahn Blood Volume 115(21):4155-4156 May 27, 2010 ©2010 by American Society of Hematology

(1) IgG antibodies to Heliobacter pylori are generated. (1) IgG antibodies to Heliobacter pylori are generated. (2) H pylori with the IgG antibodies induce platelet activation and movement of P-selectin to the platelet surface. (3) Interaction of H pylori, Hp IGs, and P-selectin leads to platelet aggregation and apoptosis, reducing the number of ciculating platelets. Professional illustration by Paulette Dennis. Yeon S. Ahn Blood 2010;115:4155-4156 ©2010 by American Society of Hematology