Controlled reoxygenation during cardiopulmonary bypass decreases markers of organ damage, inflammation, and oxidative stress in single-ventricle patients.

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Presentation transcript:

Controlled reoxygenation during cardiopulmonary bypass decreases markers of organ damage, inflammation, and oxidative stress in single-ventricle patients undergoing pediatric heart surgery Massimo Caputo, MD, Amir Mokhtari, FRCS, Antonio Miceli, MD, Mohamed T. Ghorbel, PhD, Gianni D. Angelini, FRCS, Andrew J. Parry, FRCS, Saadeh M. Suleiman, DSc The Journal of Thoracic and Cardiovascular Surgery Volume 148, Issue 3, Pages 792-801.e8 (September 2014) DOI: 10.1016/j.jtcvs.2014.06.001 Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 New York Heart Association (NYHA) class at follow-up (mean, 7 years) in (A) all patients or (B) patients with a single ventricle in the standard (hyperoxic) and controlled reoxygenation groups. The Journal of Thoracic and Cardiovascular Surgery 2014 148, 792-801.e8DOI: (10.1016/j.jtcvs.2014.06.001) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Cardiac function classification in single-ventricle patients in the standard (hyperoxic) and controlled reoxygenation groups. The change in classification between the preoperative and long-term outcomes was significantly (P < .01, Mann-Whitney U test for unpaired comparison) improved with controlled reoxygenation compared with standard (hyperoxic) reoxygenation. The Journal of Thoracic and Cardiovascular Surgery 2014 148, 792-801.e8DOI: (10.1016/j.jtcvs.2014.06.001) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Time-related plasma changes in the geometric mean for interleukin (IL)-6, IL-10, IL-8, complement activation (C3α), macrophage migration inhibitor factor (MIF), and cortisol in patients with a single ventricle in the standard (hyperoxic) (squares) and controlled reoxygenation (diamonds) cardiopulmonary bypass (CPB) groups. Unit of concentration, ng/mL. The Journal of Thoracic and Cardiovascular Surgery 2014 148, 792-801.e8DOI: (10.1016/j.jtcvs.2014.06.001) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Time-related plasma changes in the geometric mean for troponin I, 8-isoprostane, protein S100, and α-glutathione S-transferase in patients with a single ventricle in the standard (hyperoxic) (squares) and controlled reoxygenation (diamonds) cardiopulmonary bypass (CPB) groups. Unit of concentration, ng/mL. α-GT, α-Glutathione S-transferase. The Journal of Thoracic and Cardiovascular Surgery 2014 148, 792-801.e8DOI: (10.1016/j.jtcvs.2014.06.001) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure E1 Survival at follow-up (median, 7 years) in (A) all patients and (B) patients with a single ventricle (SV) in the standard (hyperoxic) and controlled reoxygenation groups. Cum, Cumulative; IQR, interquartile range. The Journal of Thoracic and Cardiovascular Surgery 2014 148, 792-801.e8DOI: (10.1016/j.jtcvs.2014.06.001) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure E2 Time-related plasma changes in the geometric mean for interleukin (IL)-6, IL-10, IL-8, complement activation (C3α), macrophage migration inhibitor factor (MIF), and cortisol in patients with a double ventricle in the standard (hyperoxic) (squares) and controlled reoxygenation (diamonds) cardiopulmonary bypass (CPB) groups. Unit of concentration, ng/mL. The Journal of Thoracic and Cardiovascular Surgery 2014 148, 792-801.e8DOI: (10.1016/j.jtcvs.2014.06.001) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure E3 Time-related plasma changes in the geometric mean for troponin I, 8-isoprostane, protein S100, and α-glutathione S-transferase in patients with a double ventricle in the standard (hyperoxic) (squares) and controlled reoxygenation (diamonds) cardiopulmonary bypass (CPB) groups. Unit of concentration, ng/mL. The Journal of Thoracic and Cardiovascular Surgery 2014 148, 792-801.e8DOI: (10.1016/j.jtcvs.2014.06.001) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions