Intravenous antibiotics given for 2 weeks do not eradicate persistent Staphylococcus aureus clones in cystic fibrosis patients C. Andersen, B.C. Kahl,

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Intravenous antibiotics given for 2 weeks do not eradicate persistent Staphylococcus aureus clones in cystic fibrosis patients C. Andersen, B.C. Kahl, H.V. Olesen, S. Jensen-Fangel, N. Nørskov-Lauritsen Clinical Microbiology and Infection Volume 20, Issue 5, Pages O285-O291 (May 2014) DOI: 10.1111/1469-0691.12406 Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1 Population dynamics of Staphylococcus aureus, other bacterial pathogens detected, and antimicrobial agents prescribed to ten patients with four or five sputum samples with S. aureus (six females and four males; age range, 2—41 years). Of 184 respiratory samples, 46 were positive for S. aureus. Blue diamonds and squares represent first and second persistent clones of S. aureus, respectively; a second persistent clone was observed in one patient; solitary clones are designated by blue asterisks. Yellow circle: Haemophilus nfluenzae. Red circles: Gram-negative non-fermenting rods (Pseudomonas aeruginosa, Achromobacter species, Burkholderia cepacia complex, or Stenotrophomonas maltophilia). White circles: negative samples. Patients received 81 courses of oral antimicrobial agents (black bars), 17 courses of intravenous antimicrobial agents (red bars) and 12 courses of inhaled antimicrobial agents (bars above patient lines) with activity against S. aureus. Clinical Microbiology and Infection 2014 20, O285-O291DOI: (10.1111/1469-0691.12406) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 2 Population dynamics of Staphylococcus aureus, other bacterial pathogens detected, and antimicrobial agents prescribed to ten patients with ≥ 17 sputum samples positive for S. aureus (six females and four males; age range, 4–19 years). Of 217 respiratory samples, 181 were positive for S. aureus. For interpretation of symbols, see Fig. 1. Blue triangles and circles represent third and fourth persistent clones of S. aureus, observed for three and one patients, respectively; small black crosses designate four non-stored S. aureus isolates. Brown square: methicillin-resistant S. aureus (patient no. 3). Patients received 152 courses of oral antibiotics, 45 courses of intravenous antibiotics and ten courses of inhaled antibiotics with activity against S. aureus. Clinical Microbiology and Infection 2014 20, O285-O291DOI: (10.1111/1469-0691.12406) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions