Volume 60, Issue 2, Pages (October 2015)

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Volume 60, Issue 2, Pages 189-192 (October 2015) It’s Raining Liquids: RNA Tunes Viscoelasticity and Dynamics of Membraneless Organelles Lin Guo, James Shorter Molecular Cell Volume 60, Issue 2, Pages 189-192 (October 2015) DOI: 10.1016/j.molcel.2015.10.006 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Model of RNP Granule Formation and Regulation RNP granule proteins often contain an IDR and a RRM. RNP granules can be formed by liquid-liquid phase separation, which rapidly increases the local concentration of IDR-containing proteins. Freshly formed RNP granules behave like liquid droplets that have weak interactions between molecules. Different RNAs participating in the separated liquid phase govern the biophysical properties and localization of the granules. Over time, the separated liquid phase matures to a more solid-like phase with strong interactions between molecules. Fibrillar structures are often observed within matured liquid droplets. Molecular Cell 2015 60, 189-192DOI: (10.1016/j.molcel.2015.10.006) Copyright © 2015 Elsevier Inc. Terms and Conditions