PORPHYRIN METABOLISM dr Agus Budiman L..

Slides:

Advertisements

Similar presentations

RED BLOOD CELL DESTRUCTION. A, 1,3,5,8 ALA, protoporphinogen, mito Oroporphinogen, coproporphinogen cytoplasm׀׀׀ Mitoch anemia.

Advertisements

HYPERBILIRUBINEMI Prof.Dr.Arzu SEVEN. HYPERBILIRUBINEMI (Bilirubin>1mg/dl in blood) Types of bilirubin: İndirect bilirubin=free bilirubin=unconjugated.

Krista Chau Walter Gao Sarah Son Kin Wong PHM142 Fall 2014 Instructor: Dr. Jeffrey Henderson.

OVERVIEW OF AMINO ACID METABOLISM ENVIRONMENT ORGANISM Ingested protein Bio- synthesis Protein AMINO ACIDS Nitrogen Carbon skeletons Urea Degradation (required)

HEME SYNTHESIS Prof.Dr.Arzu SEVEN. HEME SYNTHESIS Heme is synthesized from porphyrins and iron. Porphyrins are cyclic compounds formed by the linkage.

Porphyrin Metabolism.

Dental Biochemistry Lectures 39 and HEME AND HEMOGLOBIN Michael Lea.

DR AMINA TARIQ BIOCHEMISTRY

Bilirubin Metabolism & Jaundice

Degradation of heme 1Dr. nikhat Siddiqi. After approximately 120 days in the circulation, red blood cells are taken up and degraded by the reticuloendothelial.

Metabolism of heme and iron

Section 8. Amino Acid Metabolism Porphyrins, heme, bile pigments 11/22/04.

1 CLINICAL CHEMISTRY-2 (MLT 302) LIVER FUNCTION AND THE BILIARY TRACT LECTURE FOUR Dr. Essam H. Aljiffri.

Pathophysiology of Heme Synthesis Beth A. Bouchard BIOC 212: Biochemistry of Human Disease Spring 2006.

Heme Degradation & Hyperbilirubinemias

Heme Degradation & Hyperbilirubinemias Beth A. Bouchard BIOC 212: Biochemistry of Human Disease Spring 2005.

NITROGEN BIOSYNTHETIC PATHWAYS BIOC 460 DR. TISCHLER LECTURE 39.

Mohammed Alzoghaibi, Ph.D

Conversion of Amino Acids to Specialized Products 1Dr. Nikhat Siddiqi.

Pathophysiology of Heme Synthesis Beth A. Bouchard BIOC 212: Biochemistry of Human Disease Spring 2005.

275 BCH Miss Tahani Al-Shehri

Bilirubin Metabolism Mohammed Alzoghaibi, Ph.D Phone call, WhatsApp:

Dr Gihan Gawish. Liver - Anatomy and Physiology Largest organ in the body Three basic functions Metabolic Secretory Vascular Major function Excretion.

Chapter 16 Hemal Biochemistry The biochemistry and molecular biology department of CMU.

The Biochemistry of Jaundice  A collaborative effort of Group 3 Section 1C2  Members:  Animations by: Gerald Fuentes.

Porphyrin metabolism & porphyrias

Clinical Approach to Neonatal Jaundice

Porphyrins (Structure of Porphyrins) Objective: In addition to serving as building blocks for proteins, amino acids are precursor of many nitrogen-containing.

Metabolism of heme Alice Skoumalová. Heme structure:  a porphyrin ring coordinated with an atom of iron  side chains: methyl, vinyl, propionyl Heme.

HEME SYNTHESIS DR AMINA TARIQ BIOCHEMISTRY. HEME PROTEINS These are a group of specialized proteins that contain heme and globin. Heme is the prosthetic.

1- Porphyrins are cyclic compounds formed by the linkage of 4 pyrrole rings through methenyl bridges (-CH=). 2- Porphyrins differ from each other in the.

HEME CATABOLISM Prof.Dr.Arzu SEVEN. HEME CATABOLISM In one day, 70 kg human turns over = 6 gr of Hb Hb heme iron_free porphyrin iron (reuse) globulin.

Porphyrin metabolism & porphyrias. What are porphyrins ? Porphyrins Porphyrins are cyclic compounds that bind metal ions (usually Fe2+ or Fe3+) Metaloporphyrin.

Porphyrins and Porphyrias Dr. Zeyad El-Akawi Jreisat, M.D, M.A, Ph.D.

PORPHYRIAS  A group of rare disorders caused by deficiencies of enzymes of the heme biosynthetic pathway  Affected individuals have an accumulation of.

Porphyrins & Bile Pigments. Objectives After studying this chapter, you should be able to: Know the relationship between porphyrins and heme Be familiar.

Overview The Sites of Heme Biosynthesis are: 1.The liver, which synthesizes a number of heme proteins (particularly cytochrome P450). 2.The bone marrow,

1- Porphyrins are cyclic compounds formed by the linkage of 4 pyrrole rings through methenyl bridges (-CH=). 2- Porphyrins differ from each other in the.

Porphyrin metabolism & porphyrias

Dr Vivek Joshi, MD. Heme catabolism  Commonly occurs in liver and spleen  Done by reticuloendothelial cells  Most of the heme for degradation comes.

Metabolism of tetrapyrrols Pavla Balínová. Tetrapyrrols circular compounds binding a metal ion (most frequently Fe 2+ and Fe 3+ ) consist of 4 pyrrol.

Bilirubin metabolism and jaundice jaundice. Pathophysiological importance of bilirubin metabolism  It is the end product of heme degradation.  Serum.

Liver Function Tests (LFTs) Measurement of Serum Bilirubin (Total, direct &indirect) T.A. Bahiya Osrah.

Porphyrins and bile pigments Alice Skoumalová. Heme structure:  a porphyrin ring coordinated with an atom of iron  side chains: methyl, vinyl, propionyl.

METABOLISM OF BILE V.Sridevi. LEARNING OBJECTIVES Biosynthesis of bilirubin and bile acids/salts Causes of hyperbilirubinemia.

T.A. Bahiya Osrah.   Bilirubin is the product of heme degradation  (80% hemoglobin, 20% other hemo-protein as cytochrome, myoglobin).  Elevated levels.

M.Prasad Naidu MSc Medical Biochemistry, Ph.D.Research Scholar.

Conversion of amino acids to specialized

Metabolismo del Heme. Figure 7.3: Comparison of myoglobin and hemoglobin. © Irving Geis.

PORPHYRIN METABOLISM JANE NYANDELE DEPT. OF BIOCHEMISTRY HKMU.

Liver and biliary tract disorders. Synthesis of plasma proteins Albumin, prealbumin, transferin, coagulations factors…. Detoxication reactions of endogen.

Bilirubin metabolism and jaundice

Iron and heme metabolism

Dr. Shumaila Asim Lecture # 7

Heme Metabolism.

Molecules derived from Amino Acids

Aino Pynttäri & Margareta Kurkela

Dr. Shumaila Asim Lecture # 8

Conversion of amino acids to specialized

Lecturers of Medical Biochemistry and Molecular Biology

Metabolism of porphyrins: metabolism of bile pigments, biochemistry of jaundices. 1.

Porphyrins and bile pigment

Structure, function and metabolism of hemoglobin

Porphyrin and Heme Metabolism

Porphyrin metabolism & porphyrias

Dr. Shumaila Asim Lecture # 2

Conversion of Amino Acids to Specialized Products

Amphibolic Activity of Amino Acids

Prof. of Medical Biochemistry

Presentation transcript:

PORPHYRIN METABOLISM dr Agus Budiman L.

Porphyrins are cyclic compounds formed by the linkage of four pyrrole rings through methenyl bridges. Characteristic property of porphyrins is the formation of complexes with metal ions e.g. iron porphyrins in heme and magnesium porphrins in chlorophyll.

Examples of natural porphyrins in human and animal are hemoglobin, myoglobin, cytochrome c , cytochrome P450, catalase and tryptophan pyrrolase.

Heme synthesis begins with production of ALA (δ aminolevulinat) which succinyl-CoA and glycine are the sources and ALA synthase and pyridoxal phosphate( coenzyme) and occurs at mitochondria of living cells. Afterwards with ALA dehydratase (in cytosol) to produce porphobilinogen ( precursor of pyrrole).

ALA 1 synthase is the key regulatory enzymes in liver that regulate heme synthesis. Synthesis of heme from porphobilinogen through ferrochelatase. Porphyrias are genetic disorders of heme metabolism.

-In adult human erythrocyte could live for about 3 months and destroyed mainly in reticuloendothelial cells of liver, spleen and bone marrow. Catabolism of heme carried out in the microsomal fractions of cells by heme oxygenase complex. Hemin--- heme---biliverdin----bilirubin with NADPH.

Bilirubin bound with albumin to go to liver. Bilirubin uptake in liver with facilitated transport system. Bilirubin conjugation with glucuronic acid in liver( induced by phenobarbital). Bilirubin secreted into bile.

Three kinds of jaundice (icterus) are 1. hemolytic (prehepatic) icterus. 2. hepatic icterus. 3. obstructive (posthepatic icterus).

Unconjugated hyperbilirubinemia: Neonatal jaundice is a unconjugated hyperbilirubinemia because the enzymes UDP glucuronyl transferase are reduced. Crigler-Najjar syndrome Gilbert syndrome Toxic Hyperbilirubinemia

Conjugated hyperbilirubinemia: Obstructive of the biliary tree. Dubin-Johnson syndrome. Rotor syndrome. In hepatitis : both are unconjugated and conjugated hyperbilirubinemia.