Parkinson’s Common neurodegenerative disorder ~10-20/1000

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Parkinson’s Common neurodegenerative disorder ~10-20/1000 Expected increase of 25-30% in next 25 yrs Complex condition which changes with time Motor system-fine balance of inhibitory and excitatory inputs of basal ganglia and cerebellum Apoptosis of dopaminergic neurons in substantia nigra-leads to decrease in inhibition Disruption of signals to motor cortex via thalamus Smooth, coordinated movement is lost Genetic linkage, Up to 20% have a relative affected 30-50% have depressive symptoms No cure but treatments to increase dopamine levels

Team Workshop 1: Locate (BRAIN MAP) and label the substantia nigra Team Workshop 1: Locate (BRAIN MAP) and label the substantia nigra? Why does damage to this area affect motor coordination?

Coronal-DOPA Pet scan HC PD

18F Team Workshop 2: Draw the form of L-Dopa used for PET scan determination of Parkinson's. Why is this form used?

Team Workshop 3: Determine the most abundant type of dopamine receptor Team Workshop 3: Determine the most abundant type of dopamine receptor. Use the BRAIN ATLAS to explore where this receptor is most highly expressed in the human brain and where it is the least expressed. What can you conclude about receptor location and Parkinson's. What about alpha-synuclein?

Team Workshop 4: Amyloid has been reported to cause nitrosylation of a variety of proteins. Find other proteins reported to be nitrosylated in the presence of amyloid. What form of amyloid did they use in this experiment? Is this a good model to compare against a-synuclein?

Remember Before 12 PM of the next class day: go to b.socrative.com/student/login and complete the quiz