Autoimmune liver disease, autoimmunity and liver transplantation Marco Carbone, James M. Neuberger  Journal of Hepatology  Volume 60, Issue 1, Pages 210-223 (January 2014) DOI: 10.1016/j.jhep.2013.09.020 Copyright © 2013 European Association for the Study of the Liver Terms and Conditions

Fig. 1 AIH, PBC, and PSC are complex disorders meaning they are likely associated with the effects of multiple genes in combination with environmental factors. Journal of Hepatology 2014 60, 210-223DOI: (10.1016/j.jhep.2013.09.020) Copyright © 2013 European Association for the Study of the Liver Terms and Conditions

Fig. 2 Network map showing complexity of shared genetic effects. Some shared risk loci are involved in the pathogenesis of several autoimmune disorders. These loci are clustered in the centre of the figure. Other shared risk loci are associated with only two conditions. Numerous risk loci are associated with a single disorder. It is plausible that the central loci associated with numerous conditions are those involved in autoimmunity in general, whereas risk loci specific to a given disease determine the particular phenotype. AITD, autoimmune thyroid disease; AS, ankylosing spondylitis; CeD, coeliac disease; CD, Crohn’s disease; PSC, primary sclerosing cholangitis; MS, multiple sclerosis; PBC, primary biliary cirrhosis; RA, rheumatoid arthritis; SLE, Systemic lupus erythematosus; SS, systemic sclerosis; T1DM, type 1 diabetes mellitus; UC, ulcerative colitis. Reproduced from [156]. With permission from the Editor in Chief Prof. Eric M. Gershwin. Journal of Hepatology 2014 60, 210-223DOI: (10.1016/j.jhep.2013.09.020) Copyright © 2013 European Association for the Study of the Liver Terms and Conditions

Fig. 3 Hypothetical link between autoimmunity and alloimmunity mechanisms after liver transplantation for autoimmune liver disease. Journal of Hepatology 2014 60, 210-223DOI: (10.1016/j.jhep.2013.09.020) Copyright © 2013 European Association for the Study of the Liver Terms and Conditions

Journal of Hepatology 2014 60, 210-223DOI: (10. 1016/j. jhep. 2013. 09 Copyright © 2013 European Association for the Study of the Liver Terms and Conditions