Absent Response of Intracranial Melanoma Metastases Harboring BRAF V600E Sequence Variation to Vemurafenib  Donato D'Alonzo, MD, Katharina Glatz, MD  Mayo Clinic Proceedings  Volume 88, Issue 12, Pages e151-e152 (December 2013) DOI: 10.1016/j.mayocp.2013.04.033 Copyright © 2013 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 1 Macroscopic findings. Note innumerable pigmented melanoma metastases in the ileum (A) and brain (B). Mayo Clinic Proceedings 2013 88, e151-e152DOI: (10.1016/j.mayocp.2013.04.033) Copyright © 2013 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 2 Microscopic findings. A, Ileal metastasis consisting predominantly of pigment-laden macrophages and scattered viable tumor cells (hematoxylin-eosin, original magnification ×200). B, Viable brain metastasis in the frontal cortex with single interspersed melanophages (hematoxylin-eosin, original magnification ×200). C, On immunohistochemical analysis, tumor cells of the brain metastasis stained positive for the BRAF V600E sequence variation–specific antibody. Note strong staining of melanophages, BRAF V600E, VE1, (ultrared, original magnification ×200). Mayo Clinic Proceedings 2013 88, e151-e152DOI: (10.1016/j.mayocp.2013.04.033) Copyright © 2013 Mayo Foundation for Medical Education and Research Terms and Conditions