Low-dose methotrexate-induced ulcerated psoriatic plaques: A rare case

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Presentation transcript:

Low-dose methotrexate-induced ulcerated psoriatic plaques: A rare case Ming-Chun Hsu, MD, Chih-Chiang Chen, MD, PhD JAAD Case Reports Volume 1, Issue 5, Pages 264-266 (September 2015) DOI: 10.1016/j.jdcr.2015.06.003 Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Clinical pictures of ulcerated psoriatic plaques. A, Erythematous psoriatic plaque with ulcerated surface on thighs. B, Ulceration of psoriatic plaques on the right flank. JAAD Case Reports 2015 1, 264-266DOI: (10.1016/j.jdcr.2015.06.003) Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Histopathologic features of methotrexate-induced ulcerations. A, Skin biopsy section adjacent to an ulcerated lesion shows focal epidermal-dermal separation and ectatic vessels. B, Magnification shows an acanthotic epidermis with scattered dyskeratotic keratinocytes, overlying parakeratosis, and a superficial perivascular mixed inflammatory infiltrate. (Hematoxylin-eosin stain; A, low power; B, high power.) JAAD Case Reports 2015 1, 264-266DOI: (10.1016/j.jdcr.2015.06.003) Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions