Grantsmanship 101 Greg Cooper, MD

Goals Scope of grants available –NIH/NCI –ACS –Foundations Basic grant strategies Examples of funded grants

NIH Grants Training grants (T series, R25) New investigators –K07 –K08 –K23 Small grants –R03 Exploratory/Developmental –R21 Established investigators –R01

K07 Award Cancer Prevention, Control, Behavioral, and Population Sciences Career Development Award 3-5 years salary (up to $75,000) + research support (up to $30,000) Open to PhD + health professional degrees Minimum 75% effort Mentor +/- comentors Include career development + research plans

K08 Award Mentored Clinical Scientist Research Career Development Award Open to health professional degrees Includes basic + translational research Otherwise similar to K07

K23 Award Mentored Patient-Oriented Research Career Development Award Open to health professional degrees POR: conducted with human subjects (or material); mechanisms of disease, therapeutic interventions, clinical trials, development of new technologies Exclude existing data or specimens if cant be identified Otherwise similar to K07

R03 Award Small grants Shorter application Budget up to $100,000 year for 2 years Funding at higher rate at NCI

ACS Awards Mentored Research Scholar Grant Up to 5 years and up to $135,000 per year Categories: clinical and epidemiological, psychosocial, behavioral, health policy and health services, and targeted to poor and underserved (no basic science) Full time faculty, within first 4 years Minimum of 60% effort, up to $10,000 for mentor/year

Foundations Damon Runyon/Walter Winchell RWJ Subspecialty Societies

Main Structure of Grants Specific Aims Background Preliminary Studies Research Design and Methods

Specific Aims Usually 1 page (include opening paragraph with summary) Typically 2-5 Aims Organize around Sections Include hypotheses that will be tested (if not descriptive) Balance between too narrow and over- ambitious

Background Typically 2-3 pages At beginning, summarize what you will say Organize into sections/themes Include others work At end, summarize what you have said and give gaps in knowledge

Preliminary Studies Typically 6-8 pages Opening paragraph -summary Include work by yourself and co- investigators/mentors Include reprints in Appendix Summarize at end and highlight gaps in knowledge and how proposal will fill in gaps

Research Design and Methods Typically pages Introduction with model (Figure) Organize around sections Analyses – include hypotheses Include power/sample size calculations Include limitations Include implications/further studies

Career Development Plan The Candidate (included in 25 pages) –Background, Career Goals and Objectives, Career Development Activities Statements by Sponsor Environment & Institutional Commitment

Other Sections Human Subjects –Inclusion of women, minorities, children Clinical Research/Trials –Protection of human subjects –Data and safety monitoring plan References Supporting Information –Letters –Mentors section

Resubmissions Limited to 3 pages Point-by-point response If it aint broke, dont fix it