Volume 26, Issue 24, Pages 3269-3279 (December 2016) Effective Connectivity Reveals Largely Independent Parallel Networks of Face and Body Patches  Elsie Premereur, Jessica Taubert, Peter Janssen, Rufin Vogels, Wim Vanduffel  Current Biology  Volume 26, Issue 24, Pages 3269-3279 (December 2016) DOI: 10.1016/j.cub.2016.09.059 Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure 1 Face and Body Patch Localization (A–C) Face and body patches (faces versus bodies-objects-fruits-hands and bodies versus faces-objects-fruits-hands, respectively, for monkey D; p < 0.05, FWE corrected) plotted on anatomical T1 MRI image with electrodes inserted in (A) AL, (B) ML, and (C) mBody. See also Figure S1. Electrode tracks are indicated with arrows. Dotted white lines in sagittal sections indicate location of coronal section. Note that two electrodes were lowered in the MRI displayed in (B) (toward ML and mBody), causing the electrode reaching mBody (indicated by the blue arrow) to be visible to the left of the green arrow in the coronal slice in (B). (D) Left: coronal sections showing electrode locations for AL, ML, and mBody patch. Insets in red boxes show where neurons have been recorded (red lines). Right: face (green, FSI) and body (blue, BSI) selectivity indices for AL, ML, and mBody, for monkeys D and G separately. Current Biology 2016 26, 3269-3279DOI: (10.1016/j.cub.2016.09.059) Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure 2 AL-EM and ML-EM Activate Face Patches (A) Monkey D. Upper row: template anatomy showing t score maps for the contrast AL-EM versus no-EM (green activation patterns; p < 0.05, FWE corrected). Lightning symbol indicates EM location. Red outlines indicate face localizer (p < 0.05, FWE). Lower row: ML-EM versus no-EM (p < 0.05, FWE). (B) Monkey G. Same conventions as in (A). Upper row: AL-EM. Lower row: ML-EM. Anterior-posterior (AP) levels are indicated below coronal sections. See also Figures S3 and S4. Current Biology 2016 26, 3269-3279DOI: (10.1016/j.cub.2016.09.059) Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure 3 mBody-EM Activates Body Patches Upper row: monkey D. Template anatomy shows t score maps for the contrast mBody-EM versus no-EM (blue activation patterns; p < 0.05, FWE corrected). Lightning symbol indicates EM location. Red outlines indicate body localizer (p < 0.05, FWE corrected). Lower row: monkey G, with the same conventions as in the upper row. AP levels are indicated below coronal sections. See also Figures S4 and S5. Current Biology 2016 26, 3269-3279DOI: (10.1016/j.cub.2016.09.059) Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure 4 AL-EM and mBody-EM Activate Two Largely Segregated Networks (A) AL-EM (green) and mBody-EM (blue) for monkeys D and G, plotted on M12 template anatomy (p < 0.05, FWE corrected). Overlap is shown in yellow. Lightning symbols indicate electrode locations. Upper row: monkey D; lower row: monkey G. (B) Voxel t values for contrast AL-EM versus voxel t values for contrast mBody-EM, for monkeys D (left) and G (right). Green circles indicate voxels significantly driven by AL-EM; blue crosses indicate voxels significantly driven by mBody-EM. Note that for display purposes non-significantly driven voxels are not shown (lower left quadrant). Black lines indicate significance thresholds. Dotted black line: t value = 3.1 corresponding to p < 0.001, uncorrected; full black line: t value = 4.9 corresponding to p < 0.05, FWE corrected. See also Figure S6. Current Biology 2016 26, 3269-3279DOI: (10.1016/j.cub.2016.09.059) Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure 5 ML-EM and mBody-EM Activate Two Partially Segregated Networks ML-EM (green) and mBody-EM (blue) plotted on M12 template anatomy (p < 0.05, FWE corrected). Overlap is shown in yellow. Lightning symbols indicate electrode locations. Upper row, monkey D; middle row, monkey G; lower row, monkey D: mBody-EM and ML-EM in interleaved sessions. Current Biology 2016 26, 3269-3279DOI: (10.1016/j.cub.2016.09.059) Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure 6 Face-EM and mBody-EM Activate Two Largely Segregated Networks (A) View on aBody and AL in the anterior IT cortex. Upper row: fMRI activations for monkey D, plotted on template anatomy showing, respectively, face and body patches; AL-EM versus mBody-EM; ML-EM versus mBody-EM; and ML-EM versus mBody-EM in interleaved runs. Note that the same coronal slice (AP level indicated in upper left corner) is shown per monkey. Overlapping fMRI activations are shown in yellow. Lower row: monkey G, with same conventions. (B) PSC calculated in AL (green bars) and aBody (blue bars) during, respectively, AL-EM, mBody-EM, and ML-EM (inside bars, ∗p < 0.05; above bars, ∗p < 0.01 for the interaction). Black bars indicate SEM over runs. (C) Overview. Lightning symbols indicate the stimulated patches; colored arrows point to the regions showing increased fMRI activations after stimulation of the region at the origin of the arrow (note that we do not make any inferences with regard to ortho- or antidromic stimulation effects). Black dotted lines are connections as shown by [23]. See also Figure S6. Current Biology 2016 26, 3269-3279DOI: (10.1016/j.cub.2016.09.059) Copyright © 2016 Elsevier Ltd Terms and Conditions