The DANAMI-2 Trial Danish Trial in Acute Myocardial Infarction-2 Presented at the American College of Cardiology 51st Annual Scientific Session Atlanta, GA Dr. Henning Rud Andersen for the DANAMI-2 investigators

DANAMI-2: Study Design Primary PCI Lytic therapy Primary PCI High-risk ST elevation MI patients (>4 mm elevation), Sx < 12 hrs 5 PCI centers (n=443) and 22 referring hospitals (n=1,129), transfer in < 3 hrs Lytic therapy Front-loaded tPA 100 mg (n=782) Primary PCI with transfer (n=567) Primary PCI without transfer (n=223) Death / MI / Stroke at 30 Days Stopped early by safety and efficacy committee

DANAMI-2: Centers

DANAMI-2: Primary Results Combined Transfer Sites Non-Transfer Sites P=0.0003 P=0.002 P=0.048 RRR 40% RRR 45% RRR 45% Death / MI / Stroke (%) Lytic Primary PCI Lytic Primary PCI Lytic Primary PCI

DANAMI-2: Results Stroke Death Recurrent MI Lytic Primary PCI Lytic