The amino‐terminal regulatory domain of Mcl1.

Slides:

Advertisements

Similar presentations

Using A Tyrosine-Kinase inhibitor to regulate JNK pathways and see its effect as a possible treatment for Parksinson’s Disease By: Sobi Abbasi.

Advertisements

The Virtual Free Radical School Cell Signaling by Oxidants: Mitogen-Activated Protein Kinases (MAPK) and Activator Protein – 1 (AP-1) Brooke T. Mossman*

Malignant Melanoma and CDKN2A

Signal Response and Amplification

Human embryonic stem cells Human induced pluripotent stem cells Yamanaka S. et al. Cell 2007 Thomson J. et al. Science 2007.

Groucho suppresses Pax2 transactivation by inhibition of JNK-mediated phosphorylation The EMBO Journal Vol. 22 No. 20 pp , 2003.

Cell death vs Cell life. Characteristic morphologic features of apoptosis Extr signal Intr signal nucleus DNA fragmentation (formation of nucleosomal.

Date of download: 6/9/2016 Copyright © The American College of Cardiology. All rights reserved. From: Cardiomyocyte-Specific Deletion of Gsk3α Mitigates.

Date of download: 6/22/2016 Copyright © 2016 McGraw-Hill Education. All rights reserved. The protein products of tumor-suppressor genes often function.

Protease Activated Receptors (PARs) Molecular Cell Biology, 2013 Paul Bauer Jens Berndtsson Eva Darai Adams et al. 2011, Pharmacology & Therapeutics Coughlin.

Date of download: 7/3/2016 Copyright © The American College of Cardiology. All rights reserved. From: Targeted Inhibition of β-Adrenergic Receptor Kinase-1–Associated.

Prime Time for JNK-Mediated Akt Reactivation in Hypoxia-Reoxygenation

Prolyl‐hydroxylase‐domain proteins regulate hypoxia inducible factor‐α in response to O2 availability. Prolyl‐hydroxylase‐domain proteins regulate hypoxia.

D4476 inhibits the phosphorylation of FOXO1a at Ser322 and Ser325, but not at Thr24 in vitro. D4476 inhibits the phosphorylation of FOXO1a at Ser322 and.

The effect of amino acid substitution in the kinase inhibitory region of JAB. (A) Unchanged amino acids are shown as dots, substituted amino acids by a.

Signal Transduction by the JNK Group of MAP Kinases

Figure 1 CTLA-4 and PD-1–PD-L1 immune checkpoints

Figure 2 Crosstalk between TGF-β/Smad and other pathways in tissue fibrosis Figure 2 | Crosstalk between TGF-β/Smad and other pathways in tissue fibrosis.

Expression of adenylyl cyclases and miR‐142‐3p in CD4+CD25− T cells and CD4+CD25+ regulatory T cells. Expression of adenylyl cyclases and miR‐142‐3p in.

JNK is activated by Wnt5a.

Figure 2 The unfolded protein response

1,25‐dihydroxyvitamin D3 and retinoic acid induce p19ink4d expression.

Face‐to‐face kinase domain dimerisation of human Ire1α.

Merlin and ERM protein domain organization and phosphoregulation.

The N‐terminus and SH2 domain of SOCS‐1 contribute to inhibition of JAK1 and JAK2 kinase activity. The N‐terminus and SH2 domain of SOCS‐1 contribute to.

Calcium regulates ERK nuclear association, but not its activation.

Effect of β‐DG on activity of MEK and ERK

Model for mitosis‐induced apoptosis.

Measurement of terminal restriction fragments (TRFs) in bone marrow cells from both parents and the G4 progeny. Measurement of terminal restriction fragments.

Import of NH‐Idp3p‐, PTS‐1 (3HAD)‐ and PTS2 (3‐ketoacyl‐CoA thiolase)‐containing proteins in wild‐type, Δpex5 and Δpex7 cells. Import of NH‐Idp3p‐, PTS‐1.

NS3 inhibits endogenous miRNA action.

B lymphocytes produce antibodies.

Interaction of xFRS2 with the Src family kinase Laloo.

A model for dual inhibition of BCL2 and MCL1 to release BIM and induce apoptosis. A model for dual inhibition of BCL2 and MCL1 to release BIM and induce.

Sequence and comparison of the SDS protein.

PGAM5 associates with and activates ASK1.

Control of IL‐6 synthesis by ζPKC and RelA Ser311 phosphorylation.

A model for Mcl1 regulation of Bak‐dependent MOMP

Dynamics of cell–cell repulsion regulated by PYK2 localized at focal adhesions in migrating cells. Dynamics of cell–cell repulsion regulated by PYK2 localized.

Nat. Rev. Endocrinol. doi: /nrendo

Nat. Rev. Nephrol. doi: /nrneph

Thermal profiling identifies kinases involved in PI3K/AKT/mTOR signaling and glycolytic metabolism as palbociclib targets Thermal profiling identifies.

FOXO3 is phosphorylated by cyclin D3/CDK6 complex on S325

Ras Pathway Activation in Malignant Mesothelioma

PKB Binding Proteins Cell

The FKBP8‐ATG8 interaction is dependent on an intact LIR docking site (LDS)‏ The FKBP8‐ATG8 interaction is dependent on an intact LIR docking site (LDS)

(A) Schematic representation of full‐length APC

The Hedgehog signalling pathway.

Regulation of protein phosphatase-1

Anette Hübner, Tamera Barrett, Richard A. Flavell, Roger J. Davis

Trop‐2 can bind to IGF‐1 and interfere with IGF‐1R signalling.

WES identification of heterozygous compound mutations in ALPI

Regulation of RECQ4–MCM10 interaction by CDK phosphorylation.

WES identification of heterozygous compound mutations in ALPI

Participation of cell cycle regulators in the different stages of adipogenesis. Participation of cell cycle regulators in the different stages of adipogenesis.

Xiang-Jiao Yang, Serge Grégoire Molecular Cell

Signaling to Chromatin through Histone Modifications

Tobias B. Huber, Gerd Walz, E Wolfgang Kuehn Kidney International

(A) Deduced amino acid sequence of the D2SV cDNA cloned from the mouse heart RNA. The novel 20 amino acid C-terminus (CT) is underlined. (A) Deduced amino.

Components and outcomes of selected TNF-superfamily signalling pathways. Components and outcomes of selected TNF-superfamily signalling pathways. (Left)

Effects of streptozotocin treatment on several kinases that can phosphorylate tau. Effects of streptozotocin treatment on several kinases that can phosphorylate.

The Salt-Inducible Kinases: Emerging Metabolic Regulators

Susan S. Taylor, Nina M. Haste, Gourisankar Ghosh Cell

Phases of the Cell Cycle

Programming cancer cells for high expression levels of Mcl1

Phases of the Cell Cycle

Primary structure of zebra finch CREB

Oncogenic mutations Oncogenic mutations Examples of oncogene activating mutations are depicted. (A) Gene amplification leading to increased expression.

Topology of human Cx26 and Cx43 indicating crucial domains as well as peptides that affect protein and channel functions. Topology of human Cx26 and Cx43.

A Common Phosphate Binding Site Explains the Unique Substrate Specificity of GSK3 and Its Inactivation by Phosphorylation Sheelagh Frame, Philip Cohen,

Presentation transcript:

The amino‐terminal regulatory domain of Mcl1. The amino‐terminal regulatory domain of Mcl1. As described in the text, this long (approximately 170 aa), flexible region is unique to Mcl1 among pro‐survival Bcl2 proteins and is replete with regulatory sites. In addition to descriptions in the text, discussions about specific sites can be found in reference [5] and below. With the exception of L33 (mouse), amino acid number refers to the human sequence. Ser 64 can be phosphorylated by Cdk1 and Cdk2, and by Jnk1, which does not affect the protein half‐life but leads to an enhanced survival function [96]. Erk1 phosphorylates Thr 92 and Thr1 63, which stabilizes Mcl1 through protein association with Pin [97]. Ser 121 in conjunction with Thr 163 is phosphorylated by Jnk, resulting in enhanced stability in one study [98] and unchanged stability but less potency at inhibiting apoptosis in a different study [99]. Ser 155 phosphorylation by Gsk3 decreases Mcl1 expression [69]. Ser 159 phosphorylation leads to Mcl1 destabilization and inhibits interaction with Bim [74], whereas phosphorylation of Thr 163 by Erk increases the half‐life of Mcl1 [100]. Bcl2, B‐cell lymphoma 2; Bim, Bcl2‐like 11; Cdk1/2, cyclin‐dependent kinase 1/2; Erk1, extracellular regulated protein kinase 1; Gsk3, glycogen synthase kinase 3; Jnk1, c‐jun N‐terminal kinase 1; Mcl1, myeloid cell leukaemia 1; PEST, proline/glutamic acid/serine/threonines; Pin, peptidyl‐prolyl cis‐trans isomerase NIMA interacting protein. Franziska Ertel et al. EMBO Rep. 2013;14:328-336 © as stated in the article, figure or figure legend