Immunotherapies: Key Considerations in the Identification and Management of irAEs

This program will include a discussion of off-label treatment and investigational agents not approved by the FDA for use in the US, and data that were presented in abstract form. These data should be considered preliminary until published in a peer-reviewed journal.

Immunotherapy Is a Broad Field

Mode Of Action of Checkpoint Blockade

Approved Checkpoint Inhibitors

irAEs

irAEs of Particular Concern

Case 1: 54-Year-Old Woman

Diagnosis of Rash as an irAE

Management of Immune-Related Rash

Case 1 Follow-Up

Diagnosis of Hypothyroidism as an irAE

Management of Hypothyroidism

Case 2: 67-Year-Old Woman

Diagnosis of Colitis as an irAE

Management of Colitis

Case 2 Follow-Up

Diagnosis of Hepatitis as an irAE

Management of Hepatitis

Routine Monitoring Recommendations

General irAE Management Strategies

Cardiotoxicity as an irAE

Clinical Pearls

Abbreviations

Abbreviations (cont)

Abbreviations (cont)