An Unnatural PIP Simulates Growth Factor Signaling

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An Unnatural PIP Simulates Growth Factor Signaling Laura Swan Chemistry & Biology Volume 16, Issue 11, Pages 1127-1128 (November 2009) DOI: 10.1016/j.chembiol.2009.11.003 Copyright © 2009 Elsevier Ltd Terms and Conditions

Figure 1 The Distribution of Different PIP Species in Cellular Membranes The most abundant PIP species, PI(4,5)P2 and PI4P, are predominantly found in the plasma membrane and Golgi, respectively. PI(3,4,5)P3 is transiently produced at the plasma membrane by PI 3′-kinases acting on PI(4,5)P2 in response to growth factor receptor activation. Image kindly provided by Dr. Andrea Raimondi (De Camilli Lab). Chemistry & Biology 2009 16, 1127-1128DOI: (10.1016/j.chembiol.2009.11.003) Copyright © 2009 Elsevier Ltd Terms and Conditions