What is the role of Sildenafil Citrate to treat Erectile Dysfunction?

A review on Sildenafil citrate Active ingredient present in the brand Viagra. FDA approved drug used to treat erectile dysfunction (ED). A safe and effective drug for treatment of ED. Its generic dosage forms are very popular among men distressed from ED due to its low price. A prototype PDE-5 inhibitor and first of its class to treat ED

Mechanism of Action Sildenafil Citrate dissolves speedily in bloodstream Sildenafil Citrate Overturns the action and level of PDE5 enzyme. Increases the levels of Nitric oxide. Increases production of cGMP In the body This causes muscles to relax and the arteries to dilate in the penile region. Increases blood flow to the penis and less blood flow out of the penis. Therefore penis is filled with blood Leads to stiff and firm erections which lasts for a longer duration.

Dose Instructions Recommended dose is 100mg to be taken once a day Always take this medicine with a glass full of water. Never chew, crush or break this tablet before ingesting. Maintain a 24 hours gap between two doses. Take this medicine only when required, before planning to have a sexual encounter. Do not take this medicine on a daily basis.

Side effects Nausea Vomiting Headache Dizziness Muscle pain Nasal congestion Blurry vision Swelling of face, mouth and tongue Hives

Precautions and Warnings Take this medicine only after a gap of 24 hours from the prior dose. Always consult a doctor before starting Sildenafil Citrate. Avoid the following when on Sildenafil citrate therapy: Alcohol Tobacco Grapefruit products Nitrate containing drugs Alpha blockers Other PDE5 inhibitors Outdoor activities To be used on ‘as needed’ basis, regular use is not recommended. Sternly prohibited in women and children. Do not overdose

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