The effect of alpha lipoic acid in a porcine in-stent restenosis model

Slides:

Advertisements

Similar presentations

Impact of plaque components on no-reflow phenomenon after stent deployment in patients with acute coronary syndrome: a virtual histology-intravascular.

Advertisements

Efficacy of Drug-Eluting Stents for Treating In-Stent Restenosis of Drug-Eluting Stents (from the Korean DES ISR Multicenter Registry Study [KISS]) Young-Guk.

Endoplasmic reticulum stress influences bronchial asthma pathogenesis by modulating nuclear factor κB activation So Ri Kim, MD, PhD, Dong Im Kim, MS, Mi.

Short-term efficacy and safety of zonisamide as adjunctive treatment for refractory partial seizures: A multicenter open-label single-arm trial in Korean.

Volume 60, Issue 3, Pages (September 2012)

Acquired C797S Mutation upon Treatment with a T790M-Specific Third-Generation EGFR Inhibitor (HM61713) in Non–Small Cell Lung Cancer Haa-Na Song, MD,

IL-18 Downregulates Collagen Production in Human Dermal Fibroblasts via the ERK Pathway Hee Jung Kim, Seok Bean Song, Jung Min Choi, Kyung Moon Kim,

Effect of abciximab-coated stent on in-stent intimal hyperplasia in human coronary arteries Young Joon Hong, MD, Myung Ho Jeong, MD, PhD, Weon Kim, MD,

Alpha-lipoic acid inhibits fractalkine expression and prevents neointimal hyperplasia after balloon injury in rat carotid artery Kyeong-Min Lee, Keun-Gyu.

Volume 64, Issue 2, Pages (August 2014)

Volume 54, Issue 1, Pages (August 2009)

Who Are Less Likely to Receive Subsequent Chemotherapy Beyond First-Line Therapy for Advanced Non-small Cell Lung Cancer?: Implications for Selection.

High-mobility group box-1 protein induces osteogenic phenotype changes in aortic valve interstitial cells Bo Wang, PhD, Fei Li, MD, Chao Zhang, PhD,

Changes in Serologic Markers of Hepatitis B Following Autologous Hematopoietic Stem Cell Transplantation Ji Eun Uhm, Kihyun Kim, Tae Kyu Lim, Byeong-Bae.

Reduced hind limb ischemia-reperfusion injury in Toll-like receptor-4 mutant mice is associated with decreased neutrophil extracellular traps Rahmi Oklu,

Sustained orbital shear stress stimulates smooth muscle cell proliferation via the extracellular signal-regulated protein kinase 1/2 pathway Hidenori.

Two Cases of Small Cell Lung Cancer Transformation from EGFR Mutant Adenocarcinoma During AZD9291 Treatment Jun Soo Ham, MD, Seokhwi Kim, MD, Hee Kyung.

MET Exon 14 Skipping Mutations in Lung Adenocarcinoma: Clinicopathologic Implications and Prognostic Values Geun Dong Lee, MD, PhD, Seung Eun Lee, MD,

Who Are Less Likely to Receive Subsequent Chemotherapy Beyond First-Line Therapy for Advanced Non-small Cell Lung Cancer?: Implications for Selection.

Inhibition of the MEK/ERK pathway reduces microglial activation and interleukin-1-beta expression in spinal cord ischemia/reperfusion injury in rats

TSLP Induces Mast Cell Development and Aggravates Allergic Reactions through the Activation of MDM2 and STAT6 Na-Ra Han, Hyun-A Oh, Sun-Young Nam, Phil-Dong.

TSLP Down-Regulates S100A7 and ß-Defensin 2 Via the JAK2/STAT3-Dependent Mechanism Hana Lee, Woo-In Ryu, Hee Joo Kim, Hyun Cheol Bae, Hwa Jung Ryu, Jung.

Cross-Regulation of Proinflammatory Cytokines by Interleukin-10 and miR-155 in Orientia tsutsugamushi-Infected Human Macrophages Prevents Cytokine Storm

Acquired C797S Mutation upon Treatment with a T790M-Specific Third-Generation EGFR Inhibitor (HM61713) in Non–Small Cell Lung Cancer Haa-Na Song, MD,

Short-term efficacy and safety of zonisamide as adjunctive treatment for refractory partial seizures: A multicenter open-label single-arm trial in Korean.

The cyclolignan picropodophyllin attenuates intimal hyperplasia after rat carotid balloon injury by blocking insulin-like growth factor-1 receptor signaling

Tuberculous cellulitis as a manifestation of miliary tuberculosis in a patient with malignancy-associated dermatomyositis Ji Eun Kim, MD, Joo Yeon Ko,

The BIM Deletion Polymorphism and its Clinical Implication in Patients with EGFR- Mutant Non–Small-Cell Lung Cancer Treated with EGFR Tyrosine Kinase Inhibitors

Yong An, MD, Ying-Bin Xiao, MD

Ovarian leiomyoma as a potential cause of compromised fertility

The selective progesterone receptor modulator CDB4124 inhibits proliferation and induces apoptosis in uterine leiomyoma cells Xia Luo, Ph.D., Ping Yin,

Clinical outcomes for endovascular repair of abdominal aortic aneurysm with the Seal stent graft Jeong Ho Kim, MD, Young Kwon Cho, MD, Tae-Seok Seo,

Transforming growth factor-β increases vascular smooth muscle cell proliferation through the Smad3 and extracellular signal-regulated kinase mitogen-activated.

H2O2 Accumulation by Catalase Reduction Changes MAP Kinase Signaling in Aged Human Skin In Vivo Mi Hee Shin, Gi-eun Rhie, Yeon Kyung Kim, Chi-Hyun Park,

IL-17 enhances the migration of B cells during asthma by inducing CXCL13 chemokine production in structural lung cells Roua Al-Kufaidy, MS, Alejandro.

Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: Role of Smad1 and extracellular signal-regulated.

Effects of Alpha-Lipoic Acid on Body Weight in Obese Subjects

P21-Activated Kinase 4 Critically Regulates Melanogenesis via Activation of the CREB/MITF and β-Catenin/MITF Pathways Cheong-Yong Yun, Soon-Tae You,

Erlotinib Monotherapy for Stage IIIB/IV Non-small Cell Lung Cancer: A Multicenter Trial by the Korean Cancer Study Group Ji Eun Uhm, MD, MSc, Byeong-Bae.

Ambient pressure upregulates nitric oxide synthase in a phosphorylated-extracellular regulated kinase– and protein kinase C–dependent manner Angela G.

Paricalcitol attenuates cyclosporine-induced kidney injury in rats

P16Ink4a Suppression of Lung Adenocarcinoma by Bmi-1 in the Presence of p38 Activation Mi-Ok Lee, MSc, Hyeon-Jae Lee, MD, Mi-Ae Kim, MD, Eun-Kyung Kim,

Overexpression of Cathepsin S Induces Chronic Atopic Dermatitis in Mice Nari Kim, Ki Beom Bae, Myoung Ok Kim, Dong Hoon Yu, Hei Jung Kim, Hyung Soo Yuh,

Comparison of cell-type-specific vs transmural aortic gene expression in experimental aneurysms Eiketsu Sho, MD, PhD, Mien Sho, MD, Hiroshi Nanjo, MD,

Prolonged Activation of ERK Contributes to the Photorejuvenation Effect in Photodynamic Therapy in Human Dermal Fibroblasts Yong Hyun Jang, Gi-Bang Koo,

Volume 142, Issue 3, Pages (September 2012)

SIRT1 Activation Ameliorates Aldara-Induced Psoriasiform Phenotype and Histology in Mice Sijing Xie, Zhonglan Su, Bin Zhang, Jiuyu Ge, Shiyu Song, Guibo.

A New KIT Gene Mutation in Thymic Cancer and a Promising Response to Imatinib Sung Hee Lim, MD, Ji-Yun Lee, MD, Jong-Mu Sun, MD, PhD, Kyoung-Mee Kim,

Clinical impact of early intervention in octogenarians with non-ST-elevation myocardial infarction Zhe Hao Piao, Myung Ho Jeong, Li Jin, Da Wei Qian,

Holger Lawall, MD, Peter Bramlage, MD, PhD, Berthold Amann, MD

Jin H. Li, Xiao R. Huang, Hong-Jian Zhu, Richard Johnson, Hui Y. Lan

Transduced PEP-1-FK506BP Ameliorates Atopic Dermatitis in NC/Nga Mice

SRC and STAT Pathways Journal of Thoracic Oncology

Antisense basic fibroblast growth factor alters the time course of mitogen-activated protein kinase in arterialized vein graft remodeling Akimasa Yamashita,

MET Exon 14 Skipping Mutations in Lung Adenocarcinoma: Clinicopathologic Implications and Prognostic Values Geun Dong Lee, MD, PhD, Seung Eun Lee, MD,

Recombinant basic fibroblast growth factor inhibits the airway hyperresponsiveness, mucus production, and lung inflammation induced by an allergen challenge

IL-18 Downregulates Collagen Production in Human Dermal Fibroblasts via the ERK Pathway Hee Jung Kim, Seok Bean Song, Jung Min Choi, Kyung Moon Kim,

Integrin-β4–TNS4–Focal Adhesion Kinase Signaling Mediates Keratinocyte Proliferation in Human Skin Eun Young Seo, Seon-Pil Jin, Yeon Kyung Kim, Hanon.

A Novel Fusion of TPR and ALK in Lung Adenocarcinoma

Liver X Receptor Activation Inhibits Melanogenesis through the Acceleration of ERK- Mediated MITF Degradation Chang Seok Lee, Miyoung Park, Jiwon Han,

Insulin-Like Growth Factor-II Regulates the Expression of Vascular Endothelial Growth Factor by the Human Keratinocyte Cell Line HaCaT Yoo-Wook Kwon,

Angiogenesis and arteriogenesis in limb ischemia

Different impact of mitral regurgitation on clinical outcomes according to timing of percutaneous coronary intervention in patients with non-ST segment.

The selective progesterone receptor modulator CDB4124 inhibits proliferation and induces apoptosis in uterine leiomyoma cells Xia Luo, Ph.D., Ping Yin,

P21-Activated Kinase 4 Critically Regulates Melanogenesis via Activation of the CREB/MITF and β-Catenin/MITF Pathways Cheong-Yong Yun, Soon-Tae You,

Artificial Zinc-Finger Transcription Factor of A20 Suppresses Restenosis in Sprague Dawley Rats after Carotid Injury via the PPARα Pathway Zhaoyou Meng,

Effectiveness of different routes of misoprostol administration before operative hysteroscopy: a randomized, controlled trial Taejong Song, M.D., Mi.

Investigation on the role of necroptosis in alopecia areata: A preliminary study Yong Hyun Jang, MD, PhD, Meiling Jin, MD, Sun Young Moon, MD, Dong Hyuk.

A Dramatic Response to Crizotinib in a Non–Small-Cell Lung Cancer Patient with IHC- Positive and FISH-Negative ALK Jong-Mu Sun, MD, PhD, Yoon-La Choi,

Recombinant basic fibroblast growth factor inhibits the airway hyperresponsiveness, mucus production, and lung inflammation induced by an allergen challenge

Presentation transcript:

The effect of alpha lipoic acid in a porcine in-stent restenosis model Sang Yup Lim, MD, Eun Hui Bae, MD, Myung Ho Jeong, MD, Ju Han Kim, MD, Young Joon Hong, MD, Doo Sun Sim, MD, Yong Sook Kim, PhD, In Kyu Park, PhD, Youngkeun Ahn, MD, Sun-Jung Song, PhD, Dong Lyun Cho, PhD, Kyoung Seok Kim, MS, Jung Chaee Kang, MD Journal of Cardiology Volume 54, Issue 3, Pages 375-385 (December 2009) DOI: 10.1016/j.jjcc.2009.06.005 Copyright © 2009 Japanese College of Cardiology Terms and Conditions

Figure 1 Semiquantitative immunoblotting of phospho-p65, phosphorylated extracellular signal-regulated kinase (p-ERK), and phosphorylated signal transducers and activators of transcription (p-STAT)3 in porcine aortic smooth muscle cells. Densitometric analysis revealed increased protein expression of phospho-p65 and p-ERK after granulocyte-colony stimulating factor (G-CSF) stimulation, which was attenuated by pretreatment with α-lipoic acid (LA) in a dose-dependent manner. The protein expression of nuclear factor (NF)-κb and p-ERK were also attenuated by α-LA pretreatment. Journal of Cardiology 2009 54, 375-385DOI: (10.1016/j.jjcc.2009.06.005) Copyright © 2009 Japanese College of Cardiology Terms and Conditions

Figure 2 Columns show cell growth rate with or without pretreatment of α-lipoic acid (LA) on granulocyte-colony stimulating factor (G-CSF) induced porcine aortic smooth muscle cell proliferation by MTT (3-[4,5-dimethylthiazole-2-yl] 2,5-diphenyl tetrazolium bromide) assay. The growth rate was accelerated by G-CSF and attenuated by α-LA pretreatment. *p<0.05 compared with control cells, #p<0.05 compared with G-CSF stimulated cells. Journal of Cardiology 2009 54, 375-385DOI: (10.1016/j.jjcc.2009.06.005) Copyright © 2009 Japanese College of Cardiology Terms and Conditions

Figure 3 Methyl methacrylate (A and B) and hematoxylin and eosin (C and D) stain in the α-lipoic acid (LA) feeding study. In-stent neointimal area was smaller in the α-LA feeding group compared with the control group. (A) Control group; (B) α-LA feeding group. Magnification: 10×. α-LA feeding group shows lower inflammatory cell infiltration compared with control group. (C) Control group; (D) α-LA feeding group. Magnification: 200×. Journal of Cardiology 2009 54, 375-385DOI: (10.1016/j.jjcc.2009.06.005) Copyright © 2009 Japanese College of Cardiology Terms and Conditions

Figure 4 Methyl methacrylate (A and B) and hematoxylin and eosin (C and D) stain in the α-lipoic acid (LA) coated stent study. In-stent neointimal area was smaller in the α-LA coated stent group compared with the control group. (A) Control group; (B) α-LA coating stent group. Magnification: 10×. The α-LA feeding group showed lower inflammatory cell infiltration compared with control group. (C) Control group; (D) α-LA coated stent group. Magnification: 200×. Journal of Cardiology 2009 54, 375-385DOI: (10.1016/j.jjcc.2009.06.005) Copyright © 2009 Japanese College of Cardiology Terms and Conditions

Figure 5 Immunohistochemical staining for phosphorylated Akt and vascular endothelial growth factor (VEGF). (A) and (C) Control stent (bare metal stent); (B) and (D) α-lipoic acid (LA) coated stent. α-LA coated stent attenuated immunolabeling of p-Akt effectively after 28 days of stenting. Magnification: 200×. Journal of Cardiology 2009 54, 375-385DOI: (10.1016/j.jjcc.2009.06.005) Copyright © 2009 Japanese College of Cardiology Terms and Conditions

Figure 6 Immunohistochemical staining for phosphorylated signal transducers and activators of transcription (p-STAT)-3 and proliferating cell nuclear antigen (PCNA). (A) and (C) Control stent (bare metal stent); (B) and (D) α-lipoic acid (LA) coated stent. α-LA coated stent attenuated immunolabeling of p-STAT-3 and PCNA effectively after 28 days of stenting. Magnification: 200×. Journal of Cardiology 2009 54, 375-385DOI: (10.1016/j.jjcc.2009.06.005) Copyright © 2009 Japanese College of Cardiology Terms and Conditions