Figure 1. Study participant flowchart

Slides:

Advertisements

Similar presentations

Types of Graphs.

Advertisements

Figure 1. Flow diagram of participants recruited into the study.

Figure 1. CD11b+CD33+CD14+HLA-DR−/lo myeloid-derived suppressor cell expansion by human immunodeficiency virus.

Figure 1. Disposition of study participants, by group. Data are no

Figure 1. Forest plot: overall estimate

Figure 1. Shiga toxin–producing Escherichia coli (STEC) isolates by method of initial detection and STEC serotype, Connecticut, 2000–2009. From: Ten-Year.

Figure 1. Antibody responses against homologous 2013 H7 virus in H7N9-infected patients. A, Serum samples from H7N9-infected patients were collected at.

Interferon-α: A Potentially Effective Treatment for Minimal Residual Disease in Acute Leukemia/Myelodysplastic Syndrome after Allogeneic Hematopoietic.

From: Unmasking Masks in Makkah: Preventing Influenza at Hajj

From: Clinical and Laboratory Diagnosis of Dengue Virus Infection

Figure 1. Phenotype of CD8+ T cells and CD4+ T cells in human immunodeficiency virus (HIV)–seropositive women who are seropositive.

Figure 1. Prevalence of undocumented hepatitis C virus (HCV) infection, by age, race, and sex in 4713 emergency department patients, From: Evaluation.

Volume 66, Issue 6, Pages (June 2013)

Figure 1. Hierarchical clustering shown in a heat map of the Mouse Intestinal Tract Chip profiles of samples from mice fed the control diet or the 5% acidic.

Figure 1. Whisker-evoked intrinsic signal in S1

Figure 1. Granzyme B production by CD8+ T cells during Plasmodium berghei ANKA (PbA) infection. A, B6 mice were infected intravenously with.

Figure 1. Percentage of trainees is represented on the y-axis for each competency/knowledge item represented in the x-axis. Only Poor/Fair (P/F) ratings.

Figure 6. RRs for clinical cure rates stratified by different diseases

Figure 1. Flowchart of study participants

From: Herpes Zoster and Recurrent Herpes Zoster

Figure 5. Tungiasis: a 21-year-old woman returned from Peru with painful nodules on her toes. From: Illness in Travelers Returned From Brazil: The GeoSentinel.

Figure 3. Changes from baseline in activated CD4+ T cells (% CD4+CD25+) during the 52-week intervention period in the.

Figure 1. Percentage of infants with enzyme-linked immunosorbent assay antibody concentrations ≥0.1 IU/mL against diphtheria (day 127) and ≥0.35 μg/mL.

Selective expansion of polyfunctional pathogen-specific CD4+ T cells in HIV-1–infected patients with immune reconstitution inflammatory syndrome by Yolanda.

Characterization and quantification of clonal heterogeneity among hematopoietic stem cells: a model-based approach by Ingo Roeder, Katrin Horn, Hans-Bernd.

Adenovirus Viremia and Disease: Comparison of T Cell–Depleted and Conventional Hematopoietic Stem Cell Transplantation Recipients from a Single Institution

Multicenter study of banked third-party virus-specific T cells to treat severe viral infections after hematopoietic stem cell transplantation by Ann M.

Increased Levels of Tumor Necrosis Factor α Are Associated with an Increased Risk of Cytomegalovirus Infection after Allogeneic Hematopoietic Stem Cell.

C.-P. Kuo, C.-L. Wu, H.-T. Ho, C.G. Chen, S.-I. Liu, Y.-T. Lu

Differences in the frequency and function of HHV8-specific CD8 T cells between asymptomatic HHV8 infection and Kaposi sarcoma by Marion Lambert, Monique.

Volume 91, Issue 2, Pages (February 2017)

Volume 88, Issue 6, Pages (December 2015)

by Jayesh Mehta Blood Volume 112(2): July 15, 2008

Effects of the NK Cell Recovery on Outcomes of Unmanipulated Haploidentical Blood and Marrow Transplantation for Patients with Hematologic Malignancies

Early CMV Viremia Is Associated with Impaired Viral Control following Nonmyeloablative Hematopoietic Cell Transplantation with a Total Lymphoid Irradiation.

Assessment of cellular immunity to human cytomegalovirus in recipients of allogeneic stem cell transplants Simon F Lacey, Don J Diamond, John A Zaia

Cytomegalovirus-specific T cells are primed early after cord blood transplant but fail to control virus in vivo by Suzanne M. McGoldrick, Marie E. Bleakley,

Cytomegalovirus-Specific Cytotoxic T Lymphocytes Can Be Efficiently Expanded from Granulocyte Colony-Stimulating Factor–Mobilized Hemopoietic Progenitor.

Long-term control of recurrent or refractory viral infections after allogeneic HSCT with third-party virus-specific T cells by Barbara Withers, Emily Blyth,

Reconstitution of Natural Killer Cells in HLA-Matched HSCT after Reduced-Intensity Conditioning: Impact on Clinical Outcome Caroline Pical-Izard, Roberto.

Cytomegalovirus Immune Reconstitution Occurs in Recipients of Allogeneic Hematopoietic Cell Transplants Irrespective of Detectable Cytomegalovirus Infection

Dynamics of the Emergence of a Human Cytomegalovirus UL97 Mutant Strain Conferring Ganciclovir Resistance in a Pediatric Stem-Cell Transplant Recipient

T-cell responses against tuberculin and sensitin in children with tuberculosis and non- tuberculosis mycobacterial lymphadenopathy K. Magdorf, S.D. Schuck,

Volume 92, Issue 4, Pages (October 2017)

Biology of Blood and Marrow Transplantation

Torquetenovirus Dynamics and Immune Marker Properties in Patients Following Allogeneic Hematopoietic Stem Cell Transplantation: A Prospective Longitudinal.

Chronic Kidney Dysfunction in Patients Alive without Relapse 2 Years after Allogeneic Hematopoietic Stem Cell Transplantation Imad Abboud, Raphaël Porcher,

Allison K. Martin, BS, Douglas G. Mack, PhD, Michael T

A novel therapeutic cytomegalovirus DNA vaccine in allogeneic haemopoietic stem-cell transplantation: a randomised, double-blind, placebo-controlled,

Evidence for a Bidirectional Relationship between Cytomegalovirus Replication and acute Graft-versus-Host Disease Nathan Cantoni, Hans H. Hirsch, Nina.

Reconstitution of Interleukin-17–Producing T Helper Cells after Allogeneic Hematopoietic Cell Transplantation Felix Bahr, Rebekka Wehner, Uwe Platzbecker,

Volume 93, Issue 1, Pages (January 2018)

Relationship of BK Polyoma Virus (BKV) in the Urine with Hemorrhagic Cystitis and Renal Function in Recipients of T Cell–Depleted Peripheral Blood and.

Protective Immunity Transferred by Infusion of Cytomegalovirus-Specific CD8+ T Cells within Donor Grafts: Its Associations with Cytomegalovirus Reactivation.

Clinical Significance of Serum Hepcidin Levels on Early Infectious Complications in Allogeneic Hematopoietic Stem Cell Transplantation Junya Kanda, Chisaki.

Figure 1. CONSORT flow diagram

Figure 1. A, Crude incidence rates per 100 person-years of follow-up and 95% confidence intervals for each solid organ ... Figure 1. A, Crude incidence.

Functional analysis of clinical response to low-dose IL-2 in patients with refractory chronic graft-versus-host disease by Jennifer S. Whangbo, Haesook.

Accuracy of an immune diagnostic assay based on RD1 selected epitopes for active tuberculosis in a clinical setting: a pilot study D. Goletti, S. Carrara,

Donor Serostatus Has an Impact on Cytomegalovirus-Specific Immunity, Cytomegaloviral Disease Incidence, and Survival in Seropositive Hematopoietic Cell.

Figure 4. Levels of cerebrospinal fluid (CSF) immune and inflammatory markers in participants grouped by CSF human ... Figure 4. Levels of cerebrospinal.

Quantitative and Qualitative CD4 T Cell Immune Responses Related to Adenovirus DNAemia in Hematopoietic Stem Cell Transplantation Valérie Guérin-El Khourouj,

Donor and recipient BAL T cells are phenotypically and functionally memory T cells. Donor and recipient BAL T cells are phenotypically and functionally.

Donor TRM persistence is associated with reduced clinical complications. Donor TRM persistence is associated with reduced clinical complications. Patient.

Figure 2 Effect of DMF therapy on the T helper cell repertoire and cytokine production Effect of DMF therapy on the T helper cell repertoire and cytokine.

Volume 16, Issue 12, Pages (December 2008)

Volume 88, Issue 6, Pages (December 2015)

Relationships between species richness and temperature or latitude

Fig. 2 Dynamics of Nef-stop repair and predictors of viral set-point.

Volume 10, Issue 5, Pages (February 2015)

Presentation transcript:

Figure 1. Study participant flowchart Figure 1. Study participant flowchart. *Defined as cytomegalovirus (CMV) DNA viral load > 546 IU/mL plus use of CMV-directed antivirals. †Defined as the resolution of any level of CMV DNA without use of CMV-directed antivirals. Abbreviation: CMV, cytomegalovirus. From: Identifying Cytomegalovirus Complications Using the Quantiferon-CMV Assay After Allogeneic Hematopoietic Stem Cell Transplantation J Infect Dis. 2017;215(11):1684-1694. doi:10.1093/infdis/jix192 J Infect Dis | © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Figure 2. Cytomegalovirus (CMV)–specific responses measured 3 months after hematopoietic stem cell transplantation. Cytomegalovirus-specific responses were quantified using the Quantiferon-CMV assay to measure interferon γ (IFN-γ) production (IU/mL) (A) and CMV enzyme-linked immunosorbent spot assay to measure IFN-γ spot-forming cells (SFC/10<sup>6</sup> cells) (B) in individuals with spontaneous control (solid circles), CMV reactivation (open circles), and CMV disease (closed triangles).The horizontal line represents the median, and error bars represent the interquartile range. Abbreviations: CMV, cytomegalovirus; ELISpot, enzyme-linked immunosorbent spot assay; IFN-γ, interferon γ; SFC, spot-forming cell. From: Identifying Cytomegalovirus Complications Using the Quantiferon-CMV Assay After Allogeneic Hematopoietic Stem Cell Transplantation J Infect Dis. 2017;215(11):1684-1694. doi:10.1093/infdis/jix192 J Infect Dis | © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Figure 6. Assessment of cytomegalovirus (CMV)–specific CD4<sup>+</sup> and CD8<sup>+</sup> T-cells by intracellular cytokine staining in participants with no CMV reactivation (n = 5) and CMV reactivation (n = 5) before 3 months (A), at 3 months (B), and at 6 months after hematopoietic stem cell transplantation (C). The pie charts represent the 2 patient groups, with no CMV reactivation displayed on the left side and CMV reactivation on the right side and the cytokine profile of CMV-specific CD4<sup>+</sup> and CD8<sup>+</sup> T cells are combined. Each of the pie slices represent the proportion of cells that produce 1, 2, 3, or 4 cytokines either alone or in combination. The same data are also represented as a bar graph, where each column shows the percentage of cells that produce each cytokine in participants with (blue) or without (red) CMV reactivation. The arcs represent the proportion of total cells producing a particular cytokine and, where the arcs overlap, indicate cells producing >1 cytokine. Abbreviations: CD40L, cluster differentiation 40 ligand; IFN-γ, interferon γ; IL-2, interleukin 2; TNFα, tumor necrosis factor α. From: Identifying Cytomegalovirus Complications Using the Quantiferon-CMV Assay After Allogeneic Hematopoietic Stem Cell Transplantation J Infect Dis. 2017;215(11):1684-1694. doi:10.1093/infdis/jix192 J Infect Dis | © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Figure 5. A cumulative incidence curve of time to achieve cytomegalovirus (CMV)–specific immunity (defined as CMV interferon γ [IFN-γ] level of > 0.1 IU/mL measured by the Quantiferon-CMV assay) in participants who had spontaneous control (solid line), CMV reactivation (dashed line), and CMV disease (dotted line). Abbreviations: CMV, cytomegalovirus; HSCT, hematopoietic stem cell transplantation. From: Identifying Cytomegalovirus Complications Using the Quantiferon-CMV Assay After Allogeneic Hematopoietic Stem Cell Transplantation J Infect Dis. 2017;215(11):1684-1694. doi:10.1093/infdis/jix192 J Infect Dis | © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Figure 4. Comparison of CMV outcomes by the Quantiferon-CMV assay qualitative result. A, The relationship between the Quantiferon-CMV assay qualitative result at 3 months and clinical outcomes of spontaneous viral control, cytomegalovirus (CMV) reactivation, CMV disease and no viremia. B, Peak CMV DNA in blood in international units per milliliter. The box represents the interquartile range, with the middle horizontal bar representing the median. The whiskers represent the minimum and maximum range. Abbreviation: CMV, cytomegalovirus. From: Identifying Cytomegalovirus Complications Using the Quantiferon-CMV Assay After Allogeneic Hematopoietic Stem Cell Transplantation J Infect Dis. 2017;215(11):1684-1694. doi:10.1093/infdis/jix192 J Infect Dis | © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Figure 3. Cytomegalovirus (CMV)–specific responses measured over time for 12 months after hematopoietic stem cell transplantation (HSCT). Cytomegalovirus-specific responses were quantified using the Quantiferon-CMV assay to measure interferon γ (IFN-γ) production (IU/mL) (A) and CMV enzyme-linked immunosorbent spot assay to measure IFN-γ spot-forming cells (SFC/10<sup>6</sup> cells) (B) in individuals with spontaneous control (top row), CMV reactivation (middle row), and CMV disease (bottom row). C, Cytomegalovirus-specific responses measured over time for 12 months after HSCT using the Quantiferon-CMV assay in CMV D+/R+, CMV D−/R+, and CMV D+/R− recipients. Each dot and line in light gray represent data from a single participant. The red (if color) or gray (if grayscale) bold line represents the statistically modeled trend based on the generalized estimating equation. Abbreviations: CMV, cytomegalovirus; D, donor; ELISpot, enzyme-linked immunosorbent spot assay; HSCT, hematopoietic stem cell transplantation; IFN-γ, interferon γ; R, recipient; SFC, spot-forming cell. From: Identifying Cytomegalovirus Complications Using the Quantiferon-CMV Assay After Allogeneic Hematopoietic Stem Cell Transplantation J Infect Dis. 2017;215(11):1684-1694. doi:10.1093/infdis/jix192 J Infect Dis | © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.