The interferon gene signature is increased in patients with early treatment-naive rheumatoid arthritis and predicts a poorer response to initial therapy

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Presentation transcript:

The interferon gene signature is increased in patients with early treatment-naive rheumatoid arthritis and predicts a poorer response to initial therapy Faye A.H. Cooles, MBChB, PhD, Amy E. Anderson, PhD, Dennis W. Lendrem, PhD, Julie Norris, BSc, Arthur G. Pratt, MBChB, PhD, Catharien M.U. Hilkens, PhD, John D. Isaacs, MBBS, PhD Journal of Allergy and Clinical Immunology Volume 141, Issue 1, Pages 445-448.e4 (January 2018) DOI: 10.1016/j.jaci.2017.08.026 Copyright © 2017 The Authors Terms and Conditions

Fig 1 IGS in patients with early RA: Prevalence and disease activity associations. Patients with early RA (n = 50), established RA (n = 25), and established SLE (n = 23) and healthy control subjects (HC; n = 23) had their whole blood IGS measured. A, Proportion of patients with a positive IGS in patients with early RA (42%), established RA (21%), and SLE (56%). B, IGS expression across different disease cohorts. C, Patients with early RA (n = 11): longitudinal IGS expression at baseline (0 months) and 1, 3, and 6 months after initiation of DMARD therapy. Gray shading depicts median IGS. Box and whisker plots show medians and interquartile ranges. For both Fig 1, B and C, analysis included rank transformation of IGS scores, which were tested for differences between groups after adjustment for age and sex with the Tukey multiple comparison test applied. D and E, Plot depicts age- and sex-matched multiple regression between baseline IGS and baseline DAS28 scores in patients with early (Fig 1, D) and established (Fig 1, E) RA. F, Swollen joint count (SJC; P = .017) and tender joint count (TJC; P = .043) were the key drivers of association between baseline DAS28 scores and baseline IGS. Multiple regression analysis: *P < .05, **P < .01, and ***P < .001. Journal of Allergy and Clinical Immunology 2018 141, 445-448.e4DOI: (10.1016/j.jaci.2017.08.026) Copyright © 2017 The Authors Terms and Conditions

Fig 2 IGS in patients with early RA predicts worse disease activity, a poorer response to initial therapy, and increased glucocorticoid requirements. Patients with early RA (n = 32) had baseline IGS calculated and disease activity parameters assessed at 6 months after diagnosis and initiation of treatment. A, Plot depicts age- and sex-corrected multiple regression between baseline IGS and DAS28 scores at 6 months. B, Relationship between the probability of achieving a good EULAR response at 6 months and baseline IGS (nominal logistic regression, age and sex corrected). C, The plot depicts the relationship between the probability of receiving additional glucocorticoids in the first 6 months after diagnosis and baseline IGS. Numbers denote the number of additional glucocorticoid administrations (0-3) in the first 6 months. Baseline IGS significantly predicted additional glucocorticoid requirements (ordinal logistic regression with bootstrap probabilities included, P = .0003). The higher the baseline IGS, the greater the probability that patients fall into the regions indicating 1 or more additional glucocorticoid doses. Journal of Allergy and Clinical Immunology 2018 141, 445-448.e4DOI: (10.1016/j.jaci.2017.08.026) Copyright © 2017 The Authors Terms and Conditions

Fig E1 Additional prediction model figures. Patients with early RA (n = 32) had baseline ESR levels, CRP levels, and DAS28 scores calculated, and disease activity parameters were assessed at 6 months after diagnosis and initiation of treatment. A, Plot depicts age- and sex-corrected multiple regression between baseline ESR levels, CRP levels, and DAS28 scores and DAS28 scores at 6 months. B, Relationship between the probability of achieving a good EULAR response at 6 months and baseline ESR levels, CRP levels, and DAS28 scores (nominal logistic regression age and sex corrected). C, Plot depicts the relationship between the probability of receiving additional glucocorticoids in the first 6 months after diagnosis and baseline ESR levels, CRP levels, and DAS28 scores. Numbers denote numbers of additional glucocorticoid administrations (0-3) in the first 6 months. Baseline ESR levels, CRP levels, and DAS28 scores did not significantly predict additional glucocorticoid requirements (P = .345, P = .615, and P = .699, respectively; ordinal logistic regression with bootstrap probabilities included). Journal of Allergy and Clinical Immunology 2018 141, 445-448.e4DOI: (10.1016/j.jaci.2017.08.026) Copyright © 2017 The Authors Terms and Conditions