Muscle weakness causes joint degeneration in rabbits

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Muscle weakness causes joint degeneration in rabbits A. Rehan Youssef, D. Longino, R. Seerattan, T. Leonard, W. Herzog Osteoarthritis and Cartilage Volume 17, Issue 9, Pages 1228-1235 (September 2009) DOI: 10.1016/j.joca.2009.03.017 Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Torques recorded from the quadriceps muscles of an experimental rabbit (BTX-A injected and its contra-lateral side) at three different knee angles (75°, 100°, 125°). There is a clear and distinct decrease in muscle torque in the Botox injected compared to the contra-lateral hind limb. Tw=twitch contraction, 10, 50, 100 and 200 refer to 10, 50, 100 and 200 pulses of stimulation per second of the femoral nerve which innervates the quadriceps muscles. Osteoarthritis and Cartilage 2009 17, 1228-1235DOI: (10.1016/j.joca.2009.03.017) Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Percent weakness reflects the relative decrease in torque between corresponding hind limbs in the experimental and the sham control rabbits, averaged across all knee angles and stimulation frequencies tested. Group mean and standard deviation (SD) are shown. The experimental group had a significantly greater weakness [%] than the control group (*P<0.05). Osteoarthritis and Cartilage 2009 17, 1228-1235DOI: (10.1016/j.joca.2009.03.017) Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Percent mass deficit reflects the relative decrease in total quadriceps muscle mass between the corresponding hind limbs in the experimental compared to the sham control rabbits. Group means and SD are shown. The experimental group had a significantly greater total quadriceps muscle mass deficit [%] compared to the control group (*P<0.05). Osteoarthritis and Cartilage 2009 17, 1228-1235DOI: (10.1016/j.joca.2009.03.017) Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Example of the VL muscle taken from an experimental BTX-A injected hind limb (Left), and its contra-lateral non-injected side (right). Note the atrophy seen in the BTX-A injected compared to the non-injected contra-lateral side. Osteoarthritis and Cartilage 2009 17, 1228-1235DOI: (10.1016/j.joca.2009.03.017) Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 Box plots showing the Mankin grades of the experimental and control group rabbits. Mankin grades reflected a significant difference in the degenerative changes seen in the entire retro-patellar surface and the distal 1/3 of the retro-patellar cartilage of the experimental compared to control group rabbits (*P<0.05). Within each group, Mankin grades between the different regions of the retro-patellar cartilage were different with the distal part most degenerated and the proximal part least degenerated (**P<0.05). Osteoarthritis and Cartilage 2009 17, 1228-1235DOI: (10.1016/j.joca.2009.03.017) Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

Fig. 6 Sagittal section showing an example of retro-patellar cartilage from (left) an experimental BTX-A injected limb graded with a Mankin grade of 8 and (right) its contra-lateral non-injected side graded as 5. Notice the more severe degenerative changes. Osteoarthritis and Cartilage 2009 17, 1228-1235DOI: (10.1016/j.joca.2009.03.017) Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions