Birgit T. B. G. Schjoldager, MD, DMSc, Emmeli Mikkelsen, MB, Malene R

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Presentation transcript:

Topical application of recombinant activated factor VII during cesarean delivery for placenta previa Birgit T.B.G. Schjoldager, MD, DMSc, Emmeli Mikkelsen, MB, Malene R. Lykke, MD, Jørgen Præst, MD, Anne-Mette Hvas, MD, PhD, Lars Heslet, MD, DMSc, Niels J. Secher, MD, Jannie D. Salvig, MD, PhD, Niels Uldbjerg, MD, DMSc American Journal of Obstetrics & Gynecology Volume 216, Issue 6, Pages 608.e1-608.e5 (June 2017) DOI: 10.1016/j.ajog.2017.02.024 Copyright © 2017 The Author(s) Terms and Conditions

Figure 1 Topical recombinant activated factor VII (rFVIIa) and placenta previa Acceptable bleeding from placenta site while removing rFVIIa-carrying swab. Schjoldager et al. Topical rFVIIa and placenta previa. Am J Obstet Gynecol 2017. American Journal of Obstetrics & Gynecology 2017 216, 608.e1-608.e5DOI: (10.1016/j.ajog.2017.02.024) Copyright © 2017 The Author(s) Terms and Conditions

Figure 2 Topical recombinant activated factor VII and placenta previa (PP) Estimated blood loss during cesarean delivery in PP cases and controls, P = .31. P value indicates that there is no significant difference between blood loss between groups. Schjoldager et al. Topical rFVIIa and placenta previa. Am J Obstet Gynecol 2017. American Journal of Obstetrics & Gynecology 2017 216, 608.e1-608.e5DOI: (10.1016/j.ajog.2017.02.024) Copyright © 2017 The Author(s) Terms and Conditions

Figure 3 Topical recombinant activated factor VII and placenta previa (PP) Thrombin generation: PP cases and controls prior to and after cesarean delivery. Time until initial thrombin generation (lag time), P > .99; maximum concentration of thrombin generation (peak), P = .84; time to peak of thrombin generation (ttpeak), P > .99; endogenous thrombin potential (ETP), P = .31. P values indicate whether there is significant difference between changes in laboratory variables in 2 groups. Schjoldager et al. Topical rFVIIa and placenta previa. Am J Obstet Gynecol 2017. American Journal of Obstetrics & Gynecology 2017 216, 608.e1-608.e5DOI: (10.1016/j.ajog.2017.02.024) Copyright © 2017 The Author(s) Terms and Conditions