Mature Results from a Phase II Trial of Postoperative Concurrent Chemoradiotherapy for Poor Prognosis Cancer of the Esophagus and Gastroesophageal Junction 

Slides:



Advertisements
Similar presentations
Thomas W. Rice, MD, Deepak Khuntia, MD, Lisa A. Rybicki, MS, David J
Advertisements

Phase II Trial of Nanoparticle Albumin-Bound Paclitaxel, Carboplatin, and Bevacizumab in First-line Patients with Advanced Nonsquamous Non-small Cell.
Su K. Metcalfe, MD, MPH, Michael T
Split-Course Chemoradiotherapy for Locally Advanced Non-small Cell Lung Cancer: A Single-Institution Experience of 144 Patients  Benjamin T. Gielda, MD,
Irinotecan, Carboplatin, and Imatinib in Untreated Extensive-Stage Small-Cell Lung Cancer: A Phase II Trial of the Minnie Pearl Cancer Research Network 
Siva Raja, MD, PhD, Thomas W. Rice, MD, John Ehrlinger, PhD, John R
Role of Postoperative Radiotherapy in Pathologic Stage IIIA (N2) Non–Small Cell Lung Cancer in a Prospective Nationwide Oncology Outcomes Database  Alex.
Split-Course Chemoradiotherapy for Locally Advanced Non-small Cell Lung Cancer: A Single-Institution Experience of 144 Patients  Benjamin T. Gielda, MD,
Jessica M. Titus, MD, David P. Mason, MD, Daniel P
Severe Local Toxicity after Lung Stereotactic Body Radiation Therapy: Lesional Abscess Leading to Bronchocutaneous Fistula Requiring Surgical Marsupialization 
Irinotecan, Carboplatin, and Imatinib in Untreated Extensive-Stage Small-Cell Lung Cancer: A Phase II Trial of the Minnie Pearl Cancer Research Network 
A Randomized Phase II Trial of Pemetrexed/Gemcitabine/Bevacizumab or Pemetrexed/Carboplatin/Bevacizumab in the First-Line Treatment of Elderly Patients.
Role of Postoperative Radiotherapy in Pathologic Stage IIIA (N2) Non–Small Cell Lung Cancer in a Prospective Nationwide Oncology Outcomes Database  Alex.
Patterns of Care and Treatment Outcomes of Elderly Patients with Stage I Esophageal Cancer: Analysis of the National Cancer Data Base  Amy C. Moreno,
Esophageal submucosa: The watershed for esophageal cancer
A Phase II Trial of Carboplatin and Weekly Topotecan in the First-Line Treatment of Patients with Extensive Stage Small Cell Lung Cancer  David R. Spigel,
Multimodality Treatment of Stage III Non-small Cell Lung Cancer: Analysis of a Phase II Trial Using Preoperative Cisplatin and Gemcitabine with Concurrent.
Tetsuya Mitsudomi, MD, Hirohito Tada, MD  Journal of Thoracic Oncology 
Electronic Updates for JTO Readers
IA05.01 Lung Cancer Cases Journal of Thoracic Oncology
Surgical Treatment for Octogenarians with Lung Cancer: Results from a Population- Based Series of 124 Patients  Hes A.P. Brokx, MD, Otto Visser, MD, PhD,
A Comparison of Two Stereotactic Body Radiation Fractionation Schedules for Medically Inoperable Stage I Non-small Cell Lung Cancer: The Cleveland Clinic.
A Phase II Trial of Induction Epirubicin, Oxaliplatin, and Fluorouracil, Followed by Surgery and Postoperative Concurrent Cisplatin and Fluorouracil Chemoradiotherapy.
Samuel J. Wang, MD, PhD, C David Fuller, MD, Charles R. Thomas, MD 
Postoperative Prognosis in Patients with Non-small Cell Lung Cancer According to the Method of Initial Detection  Takeshi Hanagiri, MD, PhD, Kenji Sugio,
Frank Detterbeck, MD  Journal of Thoracic Oncology 
Phase II Trial of Paclitaxel and Cisplatin in Patients with Extensive Stage Small Cell Lung Cancer: Cancer and Leukemia Group B Trial 9430  Thomas E.
Should lung transplantation be performed using donation after cardiac death? The United States experience  David P. Mason, MD, Lucy Thuita, MS, Joan M.
Bortezomib (PS-341) in Relapsed or Refractory Extensive Stage Small Cell Lung Cancer: A Southwest Oncology Group Phase II Trial (S0327)  Primo N. Lara,
An Updated Meta-Analysis of Randomized Controlled Trials Comparing Irinotecan/Platinum with Etoposide/Platinum in Patients with Previously Untreated.
Refining esophageal cancer staging
Jeffrey Bradley, MD, Issam El Naqa, PhD  Journal of Thoracic Oncology 
Survival Benefit of Surgery after Chemoradiotherapy for Stage III (N0–2) Non-Small-Cell Lung Cancer Is Dependent on Pathologic Nodal Response  Ellis Ziel,
Effects of Chemotherapy on Survival of Elderly Patients with Small-Cell Lung Cancer: Analysis of the SEER-Medicare Database  Laura C. Caprario, MD, MS,
Increasing Rates of No Treatment in Advanced-Stage Non–Small Cell Lung Cancer Patients: A Propensity-Matched Analysis  Elizabeth A. David, MD, Megan E.
Ellen Kim, MD, MPH, Siran Koroukian, PhD, Charles R. Thomas, MD 
Phase II Trial of Irinotecan, Carboplatin, and Bevacizumab in the Treatment of Patients with Extensive-Stage Small-Cell Lung Cancer  David R. Spigel,
A Phase II Study of Paclitaxel + Etoposide + Cisplatin + Concurrent Radiation Therapy for Previously Untreated Limited Stage Small Cell Lung Cancer (E2596):
Jeffrey T. Yorio, MD, Yang Xie, PhD, Jingsheng Yan, PhD, David E
Value of accelerated multimodality therapy in stage IIIA and IIIB non–small cell lung cancer  Malcolm M DeCamp, MD, Thomas W Rice, MD, David J Adelstein,
Treatment Outcomes of Different Prognostic Groups of Patients on Cancer and Leukemia Group B Trial 39801: Induction Chemotherapy Followed by Chemoradiotherapy.
Positron Emission Tomography 18F-Fluorodeoxyglucose Uptake and Prognosis in Patients with Surgically Treated, Stage I Non-small Cell Lung Cancer: A Systematic.
Short-course induction chemoradiotherapy with paclitaxel for stage III non-small-cell lung cancer  Thomas W Rice, MD, David J Adelstein, MD, Jay P Ciezki,
A Double-Blind Randomized Discontinuation Phase-II Study of Sorafenib (BAY 43– 9006) in Previously Treated Non–Small-Cell Lung Cancer Patients: Eastern.
A Simple Solution for Complicated Pleural Effusions
M1a/M1b esophageal carcinoma: Clinical relevance
DHA-Paclitaxel (Taxoprexin) as First-Line Treatment in Patients with Stage IIIB or IV Non-small Cell Lung Cancer: Report of a Phase II Open-Label Multicenter.
Role of Postoperative Radiotherapy in Nonlocalized Thymoma
Thomas W. Rice, MD, Deepak Khuntia, MD, Lisa A. Rybicki, MS, David J
Phase II Trial of Paclitaxel–Topotecan–Etoposide Followed by Consolidation Chemoradiotherapy for Limited-Stage Small Cell Lung Cancer: CALGB 30002  Antonius.
The Port Site Recurrence after a Thoracoscopic and Video-Assisted Esophagectomy for Advanced Esophageal Cancer  Satoshi Yamamoto, PhD, Katsunobu Kawahara,
Bolstering the Case for Lobectomy in Stages I, II, and IIIA Small-Cell Lung Cancer Using the National Cancer Data Base  Susan E. Combs, MA, Jacquelyn.
Gaurav Marwaha, MD, Kevin L. Stephans, MD, Neil M
RTOG 0017: A Phase I Trial of Concurrent Gemcitabine/Carboplatin or Gemcitabine/Paclitaxel and Radiation Therapy (“Ping-Pong Trial”) Followed By Adjuvant.
Recursive Partitioning Analysis Groups II–III Brain Metastases of Non-small Cell Lung Cancer: A Phase II Randomized Study Comparing Two Concurrent Chemoradiotherapy.
Phase II Trial of Paclitaxel, Carboplatin, and Topotecan with G-CSF Support in Previously Untreated Patients with Extensive Stage Small Cell Lung Cancer:
Phase II trial of postoperative adjuvant cisplatin and etoposide in patients with completely resected stage I-IIIa small cell lung cancer: The Japan Clinical.
Michael Hsie, MD, Stefania Morbidini-Gaffney, MD, Leslie J
International Thymic Malignancies Interest Group: A Way Forward
Outcome of Multimodality Treatment for 188 Cases of Type B3 Thymoma
Stage I Non-small Cell Lung Cancer: Results for Surgery in a Patterns-of-Care Study in Sydney and for High-Dose Concurrent End-Phase Boost Accelerated.
Wedge Resection for Non-small Cell Lung Cancer in Patients with Pulmonary Insufficiency: Prospective Ten-Year Survival  John P. Griffin, MD, Charles E.
Chemoradiotherapy and Gefitinib in Stage III Non-small Cell Lung Cancer with Epidermal Growth Factor Receptor and KRAS Mutation Analysis: Cancer and Leukemia.
David Garfield, MD  Journal of Thoracic Oncology 
Sorafenib in Platinum-Treated Patients with Extensive Stage Small Cell Lung Cancer: A Southwest Oncology Group (SWOG 0435) Phase II Trial  Barbara J.
Induction Therapy For Locally Advanced Thymoma
A Randomized, Phase II Trial of Two Dose Levels of Temsirolimus (CCI-779) in Patients with Extensive-Stage Small-Cell Lung Cancer Who Have Responding.
Rogerio C. Lilenbaum, MD, John Cashy, PhD, Thomas A
Effect of Tumor Size on Prognosis in Patients Treated with Radical Radiotherapy or Chemoradiotherapy for Non–Small Cell Lung Cancer: An Analysis of the.
Proceed with caution: The importance of surveillance in patients with pathologic complete response after chemoradiation therapy plus surgery for esophageal.
Presentation transcript:

Mature Results from a Phase II Trial of Postoperative Concurrent Chemoradiotherapy for Poor Prognosis Cancer of the Esophagus and Gastroesophageal Junction  David J. Adelstein, MD, Thomas W. Rice, MD, Lisa A. Rybicki, MS, Jerrold P. Saxton, MD, Gregory M.M. Videtic, MD, Sudish C. Murthy, MD, David P. Mason, MD, Cristina P. Rodriguez, MD, Denise I. Ives, RN  Journal of Thoracic Oncology  Volume 4, Issue 10, Pages 1264-1269 (October 2009) DOI: 10.1097/JTO.0b013e3181b26f8e Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Treatment schema. Journal of Thoracic Oncology 2009 4, 1264-1269DOI: (10.1097/JTO.0b013e3181b26f8e) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Representative treatment fields for delivery of postoperative radiotherapy in a patient with M1a distal esophageal cancer and close surgical margins. A, Anterior field (from a three-field technique) with blocks. B, Boost field to anastomosis. Journal of Thoracic Oncology 2009 4, 1264-1269DOI: (10.1097/JTO.0b013e3181b26f8e) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 Overall survival (n = 50 patients). Journal of Thoracic Oncology 2009 4, 1264-1269DOI: (10.1097/JTO.0b013e3181b26f8e) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 4 Overall survival by pathologic stage. Journal of Thoracic Oncology 2009 4, 1264-1269DOI: (10.1097/JTO.0b013e3181b26f8e) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions